Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey.
Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey.
复制标题
DOI：
10.1515/med-2022-0452
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Cosentino M
中科院分区：
文献类型：
--
作者：
Laganà AS;Veronesi G;Ghezzi F;Ferrario MM;Cromi A;Bizzarri M;Garzon S;Cosentino M
我们调查了第一剂和第二剂COVID-19疫苗接种后的月经不规律。女性回答了一份定制的在线问卷（ClinicalTrial.gov ID：NCT 05083065），旨在评估疫苗类型，接种疫苗的月经周期阶段，第一次和第二次接种后月经不规律的发生率，以及这种影响持续多久。我们排除了患有妇科和非妇科疾病、接受激素和非激素治疗、处于围绝经期或绝经期的妇女，以及在接种疫苗前12个月内月经周期不规则的妇女。根据我们的数据分析，约50 - 60%接种第一剂COVID-19疫苗的育龄妇女报告月经周期不规则，无论接种的疫苗类型如何。第二次给药后月经不规律的发生率似乎略高（60 - 70%）。在第一次和第二次接种疫苗后，发现大约一半的病例在两个月内自行消退。基于这些结果，我们建议在为接种COVID-19疫苗的女性提供咨询时考虑这些因素，让她们了解在随后的几个月内可能发生暂时性和自限性月经周期不规律。
We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID: NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long this effect lasted. We excluded women with gynaecological and non-gynaecological diseases, undergoing hormonal and non-hormonal treatments, in perimenopause or menopause, as well as those who had irregular menstrual cycles in the last 12 months before vaccine administration. According to our data analysis, approximately 50–60% of reproductive-age women who received the first dose of the COVID-19 vaccine reported menstrual cycle irregularities, regardless of the type of administered vaccine. The occurrence of menstrual irregularities seems to be slightly higher (60–70%) after the second dose. Menstrual irregularities after both the first and second doses of the vaccine were found to self-resolve in approximately half the cases within two months. Based on these results, we suggest to consider these elements during the counselling of women who receive the COVID-19 vaccine, letting them know about the potential occurrence of temporary and self-limiting menstrual cycle irregularities in the subsequent month(s).