Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations
Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations
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DOI：
10.1126/science.1226850
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发表时间：
2013-02-15
期刊：
影响因子：
56.9
通讯作者：
Klaminder, J.
中科院分区：
文献类型：
--
作者：
Brodin, T.;Fick, J.;Klaminder, J.
药物对环境的污染日益被认为是对全世界水生生态系统的主要威胁。各种药物通过处理后的废水进入水道，并在水生系统中保持生物化学活性。已经进行了几项生态毒理学研究，但总的来说，人们对药物的生态效应知之甚少。在这里，我们展示了一种苯二氮卓类抗焦虑药物(奥沙西潘)改变了野生欧洲鲈鱼(Perca Fluviatilis)的行为和摄食率，其浓度达到了受污水影响的地表水域的浓度。暴露在稀释药物浓度(1.8微克升(-1))的水中的个体表现出活动增加、社会性减少和更高的喂食率。因此，我们的结果表明，地表水中的抗焦虑药物会改变已知具有生态和进化后果的动物行为。
Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A variety of pharmaceuticals enter waterways by way of treated wastewater effluents and remain biochemically active in aquatic systems. Several ecotoxicological studies have been done, but generally, little is known about the ecological effects of pharmaceuticals. Here we show that a benzodiazepine anxiolytic drug (oxazepam) alters behavior and feeding rate of wild European perch (Perca fluviatilis) at concentrations encountered in effluent-influenced surface waters. Individuals exposed to water with dilute drug concentrations (1.8 micrograms liter(-1)) exhibited increased activity, reduced sociality, and higher feeding rate. As such, our results show that anxiolytic drugs in surface waters alter animal behaviors that are known to have ecological and evolutionary consequences.