Fatigue and psychological disorders in chronic hepatitis C
Fatigue and psychological disorders in chronic hepatitis C
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DOI：
10.1046/j.1440-1746.2002.02669.x
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发表时间：
2002-02-01
影响因子：
4.1
通讯作者：
Gluseska, S
中科院分区：
文献类型：
--
作者：
McDonald, J;Jayasuriya, R;Gluseska, S
背景和目的：大多数慢性丙型肝炎患者报告说他们感到疲劳。本研究的目的是确定疲劳症状是否可以指导慢性丙型肝炎的疾病活动性，或者是否与心理因素有关。方法：澳大利亚卧龙岗医院肝脏门诊的 115 名慢性丙型肝炎患者被要求填写一份关于疲劳对其功能影响的调查问卷，以及一份关于心理参数的调查问卷。这些与静脉吸毒史、饮酒史、转氨酶水平和肝活检结果相关。结果：疲劳与肝活检的纤维化水平弱相关，但与抑郁、焦虑、躯体化、人际敏感性和敌意等所有心理领域密切相关。结论：疲劳水平与所有心理领域，特别是抑郁，密切相关，而不是与我们对疾病活动的测量密切相关。 (C) 2002 Blackwell Science Asia Pty Ltd。
Background and Aim: Most patients with chronic hepatitis C report that they suffer from fatigue. The aim of this study was to determine if the symptom of fatigue can be a guide to indicate disease activity in chronic hepatitis C, or if it is related to psychological factors.Methods: 115 chronic hepatitis C patients attending a liver clinic at Wollongong Hospital, Wollongong, Australia, were asked to fill out a questionnaire on the functional impact of their fatigue, and a questionnaire on psychological parameters. These were correlated with a history of intravenous drug use, alcohol history, transaminase levels and liver biopsy findings.Results: Fatigue weakly correlated with the level of fibrosis on the liver biopsy, but strongly correlated with all the psychological domains of depression, anxiety, somatization, interpersonal sensitivity and hostility.Conclusion: The level of fatigue strongly correlated with all the psychological domains, particularly depression, and not with our measures of disease activity. (C) 2002 Blackwell Science Asia Pty Ltd.