PROLONGED EXPULSION OF ADULT TRICHINELLA-SPIRALIS AND EOSINOPHIL INFILTRATION IN MAST CELL-DEFICIENT W WV MICE
PROLONGED EXPULSION OF ADULT TRICHINELLA-SPIRALIS AND EOSINOPHIL INFILTRATION IN MAST CELL-DEFICIENT W WV MICE
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DOI：
10.1017/s0022149x00008002
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发表时间：
1985-01-01
影响因子：
1.6
通讯作者：
OHBAYASHI, M
中科院分区：
文献类型：
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作者：
KAMIYA, M;OKU, Y;OHBAYASHI, M
旋毛虫感染（WBxC57BL/6）F1-W/Wv小鼠及其窝仔WBB6F1-+/+、+/W、+/Wv小鼠的肠道和肌肉中均观察到嗜酸性粒细胞浸润，其程度几乎相同。W/Wv小鼠对螺旋体感染没有表现出上皮下肥大细胞和白细胞的浸润。在它们的幼崽中观察到这些细胞的数量增加。W/Wv小鼠体内的蠕虫比同窝小鼠体内的蠕虫留存时间更长。此外，通过被动皮肤过敏反应（PCA）和间接血凝（IHA）测定，W/Wv小鼠和它们的窝仔之间的特异性血清抗体的产生没有差异。这些结果表明SMC、GL和嗜酸性粒细胞可能参与了成螺旋体的排出。
Eosinophil infiltrations were observed in the intestine and the muscle of both Trichinella spiralis-infected (WBxC57BL/6)F1-W/Wv mice and their littermates, WBB6F1-+/+, +/W, +/Wv, almost to the same extent. W/Wv mice did not show infiltration of subepithelial mast cells and globule leucocytes in response to T. spiralis infection. Increased numbers of these cells were observed in their littermates. Worms in W/Wv mice were retained for longer periods than those in littermates. Also, no difference was noted in the production of specific serum antibodies between W/Wv mice and their littermates, as determined by passive cutaneous anaphylaxis (PCA) for specific IgE and by indirect haemagglutination (IHA). These results suggest a possible participation of SMC, GL and eosinophils in the expulsion of adult T. spiralis.