Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility
Mortality of employees of a perfluorooctanesulphonyl fluoride manufacturing facility
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DOI：
10.1136/oem.60.10.722
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发表时间：
2003-10-01
影响因子：
4.9
通讯作者：
Mandel, JS
中科院分区：
文献类型：
--
作者：
Alexander, BH;Olsen, GW;Mandel, JS
目的：为了评估一个队列的全氟辛烷磺酰氟（POSF）为基础的氟化物生产facility.Methods：一个回顾性队列死亡率研究的员工死亡率的经验，所有工人至少有一年的累积就业在设施。队列成员的工作被分配到三个暴露亚组之一：高暴露，低暴露，和非暴露，基于生物监测数据的全氟辛烷磺酸（PFOS）。结果：在2083队列成员中，共确定了145例死亡。65例死亡发生在曾从事高暴露工作的工人中。队列和暴露亚队列的总体死亡率低于一般人群的预期。在至少一年高或低暴露的工人中观察到两例肝癌死亡（标准化死亡率比（SMR）3.08，95% CI 0.37至11.10）。在整个队列中，膀胱癌死亡风险增加（观察到3例，SMR 4.81，95% CI 0.99 - 14.06）。所有三种膀胱癌均发生在从事高暴露工作的工人中（SMR 12.77，95% CI 2.63至37.35）。膀胱癌的情况下，主要工作在非生产岗位，包括维修和焚化炉和污水处理厂operation.Conclusion：工人从事高暴露工作的膀胱癌死亡人数增加，但目前尚不清楚这三种情况下是否可以归因于氟化合物暴露，一个未知的膀胱致癌物的过程中遇到的维修工作，和/或非职业暴露。由于只有三个观察到的病例，不能排除偶然发现的可能性。
Aim: To evaluate the mortality experience of a cohort of employees of a perfluorooctanesulphonyl fluoride (POSF) based fluorochemical production facility.Methods: A retrospective cohort mortality study followed all workers with at least one year of cumulative employment at the facility. The jobs held by cohort members were assigned to one of three exposure subgroups; high exposed, low exposed, and non-exposed, based on biological monitoring data for perfluorooctane sulphonate (PFOS).Results: A total of 145 deaths were identified in the 2083 cohort members. Sixty five deaths occurred among workers ever employed in high exposed jobs. The overall mortality rates for the cohort and the exposure subcohorts were lower than expected in the general population. Two deaths from liver cancer were observed in the workers with at least one year of high or low exposure (standardised mortality ratio (SMR) 3.08, 95% CI 0.37 to 11.10). The risk of death from bladder cancer was increased for the entire cohort (three observed, SMR 4.81, 95% CI 0.99 to 14.06). All three bladder cancers occurred among workers who held a high exposure job (SMR 12.77, 95% CI 2.63 to 37.35). The bladder cancer cases primarily worked in non-production jobs, including maintenance and incinerator and wastewater treatment plant operations.Conclusion: Workers employed in high exposure jobs had an increased number of deaths from bladder cancer; however it is not clear whether these three cases can be attributed to fluorochemical exposure, an unknown bladder carcinogen encountered during the course of maintenance work, and/or nonoccupational exposures. With only three observed cases the possibility of a chance finding cannot be ruled out.