The maintenance of transposable elements in natural populations.
The maintenance of transposable elements in natural populations.
复制标题
自然群体中转座因子的维持。
DOI：
10.1007/978-1-4684-5550-2_14
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Charlesworth,B
中科院分区：
文献类型：
--
作者：
Charlesworth,B
回顾了随机交配宿主群体中转座因子的维持模型。结果表明，个体之间拷贝数分布的数据与基于孟德尔元素传递的预期基本一致。讨论了面对拷贝数转座增加时，转座率调节和各种自然选择模式在维持拷贝数平衡中的作用。讨论了针对插入突变和针对位于非同源染色体位置的同源元件之间交换引起的染色体重排的选择作用的测试。讨论了预期元素在交叉受到限制的染色体区域中积累的原因，并描述了表明存在这种效应的数据。描述了单个染色体位点元素频率概率分布的理论和数据。结论是，现有的群体数据与元素丰度很大程度上受拷贝数转位增加与相反力的相互作用控制的概念一致。
Models of the maintenance of transposable elements in randomly mating host populations are reviewed. It is shown that the data on the distribution of copy numbers between individuals are largely concordant with what is expected on the basis of the Mendelian transmission of elements. The role of regulation of rates of transposition, and of various modes of natural selection, in maintaining an equilibrium in copy numbers in the face of transpositional increase in copy number is discussed. Tests for the role of selection against insertional mutations and against chromosome rearrangements induced by exchange between homologous elements located at nonhomologous chromosome locations are discussed. Reasons for expecting elements to accumulate in chromosome regions where crossing over is restricted are discussed, and data suggesting the existence of such an effect are described. Theory and data on the probability distribution of element frequencies at individual chromosomal sites are described. It is concluded that the available population data are consistent with the notion that element abundances are largely controlled by the interaction of transpositional increase in copy number with opposing forces.