Structure and expression of a chicken gene coding for U1 RNA
Structure and expression of a chicken gene coding for U1 RNA
复制标题
编码 U1 RNA 的鸡基因的结构和表达
DOI：
10.1016/0092-8674(81)90430-x
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发表时间：
1981
期刊：
影响因子：
64.5
通讯作者：
B. O’Malley
中科院分区：
文献类型：
--
作者：
D. Roop;P. Kristo;W. Stumph;M. Tsai;B. O’Malley
We have isolated and sequenced a genomic fragment containing sequences complementary to chicken Ul RNA. The sequence of this genomic Ul gene is completely homologous and colinear with that of chicken Ul RNA. This Ul gene is part of a multigene family (6-10 copies per haploid genome), and these loci do not appear to be closely clustered. Sequences complementary to other snRNAs are not present within the 2.5 kb genomic fragment containing the Ul gene. We have determined that Ul RNA is synthesized by polymerase II; however, a “Hogness box” is not present upstream from its cap site at the position usually observed for mRNA genes. The synthesis of Ul RNA in oviduct nuclei during different states of hormonal induction also appears to be constitutive.
