Ploidy of primary germ cell tumors of the testis. Pathogenetic and clinical relevance.
Ploidy of primary germ cell tumors of the testis. Pathogenetic and clinical relevance.
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睾丸原发性生殖细胞肿瘤的倍性。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
H. Koops
中科院分区：
文献类型：
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作者：
J. Oosterhuis;S. Castedo;B. Jong;C. Cornelisse;A. Dam;D. Sleijfer;H. Koops
应用流式细胞术对睾丸生殖细胞瘤（GCT）的倍体进行了研究。婴儿卵黄囊瘤（N = 10）、卵巢癌（N = 20）和非卵巢癌（N = 36）的DNA指数分别为：1.91、1.66和1.43。这些值彼此之间存在显著差异（p <0.01）。联合肿瘤的腺瘤和非腺瘤成分（N = 16）的中位数DNA指数分别为1.61和1.40，具有显著差异。10例婴儿卵黄囊瘤中3例为二倍体，而72例成人睾丸GCT中仅1例为二倍体。成人睾丸GCT的一致性异倍体可能有助于原发性睾丸非精细胞肿瘤的鉴别诊断，并有助于睾丸GCT转移瘤与原发性性腺外恶性GCT的鉴别。这些数据符合成年人睾丸GCT发病机制的模型，其中所有肿瘤，可能除了精细胞性腺瘤外，都经历了腺瘤阶段。肿瘤的演变似乎是由于（近）四倍体原位癌细胞染色体的净丢失。婴儿卵黄囊瘤的发病机制可能与成人睾丸GCT不同。
The ploidy of testicular germ cell tumors (GCT), a heterogeneous group of neoplasms, was studied by DNA flow cytometry. The DNA index for infantile yolk sac tumor (N = 10), seminomas (N = 20), and nonseminomas (N = 36), was: 1.91, 1.66, and 1.43, respectively. These values differed significantly one from another (p less than 0.01). The seminoma and nonseminoma components of combined tumors (N = 16) had a significantly different median DNA index of 1.61 and 1.40, respectively. Three of the 10 infantile yolk sac tumors, but only one of the 72 testicular GCT of adults were diploid. The consistent aneuploidy of testicular GCTs of adults might be helpful in the differential diagnosis of primary nongerm cell tumors of the testis, and in differentiating between metastases of testicular GCTs and primary extragonadal malignant GCTs. These data fit into a model of pathogenesis of testicular GCTs of adults in which all tumors, with the possible exception of spermatocytic seminoma, pass through a seminoma stage. Tumor evolution seems to result from net loss of chromosomes from a (near)tetraploid carcinoma in situ cell. The pathogenesis of infantile yolk sac tumor might be different from that of testicular GCTs of adults.