A Battery-Less, Implantable Neuro-Electronic Interface for Studying the Mechanisms of Deep Brain Stimulation in Rat Models
A Battery-Less, Implantable Neuro-Electronic Interface for Studying the Mechanisms of Deep Brain Stimulation in Rat Models
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DOI：
10.1109/tbcas.2015.2403282
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发表时间：
2016-02-01
影响因子：
5.1
通讯作者：
Chen, Hsin
中科院分区：
文献类型：
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作者：
Lin, Yu-Po;Yeh, Chun-Yi;Chen, Hsin
虽然脑深部电刺激（DBS）已成为治疗几种神经疾病的有前途的替代方案，但DBS的潜在机制仍未完全了解。由于大鼠模型提供了记录和刺激不同的疾病相关区域的优势，同时，本文提出了一种无电池，植入式神经电子接口适合于研究DBS机制与自由移动的大鼠。神经电子接口主要由一个微系统组成，能够与八个不同的大脑区域双向和同时进行交互。为了使植入物的尺寸最小化，微系统通过单个线圈接收电力并传输数据。此外，特别注意在每次刺激后立即记录神经活动的能力，以便获得关于刺激如何调节神经活动的信息。该微系统已与标准的0.18 m CMOS工艺制造。芯片面积为7.74 mm（2），微系统能够在1 V的单电源电压下工作。无线接口允许最大功率为10 mW，分别以2 Mbps或100 kbps的速率与上行链路或下行链路数据一起传输。记录放大器的输入参考噪声为1.16 μ Vrms，激励电压在1.5 V至4.5 V范围内可调，分辨率为5位。在测试微系统的电功能之后，进一步检查微系统与大鼠大脑接口的能力，并与传统仪器进行比较。所有的实验结果，本文提出和讨论。
Although deep brain stimulation (DBS) has been a promising alternative for treating several neural disorders, the mechanisms underlying the DBS remain not fully understood. As rat models provide the advantage of recording and stimulating different disease-related regions simultaneously, this paper proposes a battery-less, implantable neuro-electronic interface suitable for studying DBS mechanisms with a freely-moving rat. The neuro-electronic interface mainly consists of a microsystem able to interact with eight different brain regions bi-directionally and simultaneously. To minimize the size of the implant, the microsystem receives power and transmits data through a single coil. In addition, particular attention is paid to the capability of recording neural activities right after each stimulation, so as to acquire information on how stimulations modulate neural activities. The microsystem has been fabricated with the standard 0.18 m CMOS technology. The chip area is 7.74 mm(2), and the microsystem is able to operate with a single supply voltage of 1 V. The wireless interface allows a maximum power of 10 mW to be transmitted together with either uplink or downlink data at a rate of 2 Mbps or 100 kbps, respectively. The input referred noise of recording amplifiers is 1.16 mu Vrms, and the stimulation voltage is tunable from 1.5 V to 4.5 V with 5-bit resolution. After the electrical functionality of the microsystem is tested, the capability of the microsystem to interface with rat brain is further examined and compared with conventional instruments. All experimental results are presented and discussed in this paper.