[F-18] FLUORODEOXYGLUCOSE SCINTIGRAPHY IN DIAGNOSIS AND FOLLOW UP OF TREATMENT IN ADVANCED BREAST-CANCER
[F-18] FLUORODEOXYGLUCOSE SCINTIGRAPHY IN DIAGNOSIS AND FOLLOW UP OF TREATMENT IN ADVANCED BREAST-CANCER
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DOI：
10.1007/bf00702620
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发表时间：
1989-02-01
期刊：
影响因子：
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通讯作者：
SOINI, I
中科院分区：
文献类型：
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作者：
MINN, H;SOINI, I
对17例晚期乳腺癌患者进行了特殊准直伽马摄像，以研究治疗前后肿瘤对2-[18F]-氟-2-脱氧-D-葡萄糖(FDG)的摄取。14例(82%)转移瘤内FDG积聚增加，6/8(75%)腋窝、锁骨上或锁骨下转移淋巴结可检出。在其中一个病例中，FDG成像是第一个确定导致神经压迫的腋窝转移的方法。另外，肺和肝转移瘤也可以用FDG成像；这两种情况都发生在两个病人身上。在骨转移瘤中摄取的个体内差异很大，并且一些病灶仍为FDG阴性：99mTC-DPD在检测骨疾病方面更具优势。溶骨型或混合型骨转移灶的显示率高于硬化型骨转移灶。10名患者随后被重新成像，以评估治疗对FDG摄取的影响。摄取增加与临床进展有关，而摄取不变或减少并不能可靠地预测病程。本研究表明，FDG可用于乳腺癌转移灶的成像。FDG在监测治疗反应方面可能是有价值的，但正电子发射断层扫描(PET)可能比平面成像更适合于此目的。
Seventeen patients with advanced breast cancer were imaged with a specially collimated gamma camera to study tumor uptake of 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) before and during therapy. Fourteen patients (82%) showed increased FDG accumulation in metastatic tumors, 6/8 (75%) of axillary, supra or infraclavicular metastatic lymph nodes were detectable. In one of these cases, FDG imaging was the first method to identify axillary metastasis causing nerve compression. Also, pulmonary and liver metastases could be imaged with FDG; both in two patients. The intra individual variability in uptake was considerable in bone metastases, ans some lesions remained FDG negative: 99mTc-DPD was superior in detecting bone disease. Bone metastases of the osteolytic or mixed type were better visualized than sclerotic ones. Ten patients were reimaged later to assess the effect of therapy on FDG uptake. Increased uptake was associated with clinical progression, while unchanged or diminished uptake did not predict the course of disease as reliably. This study indicates that FDG can be used to image breast cancer metastases. FDG may be valuable in monitoring treatment response, but positron emission tomography (PET) would probably be more appropriate than planar imaging for this purpose.