Relationship between retinopathy severity, visual impairment and depression in persons with long-term type 1 diabetes.
Relationship between retinopathy severity, visual impairment and depression in persons with long-term type 1 diabetes.
复制标题
DOI：
10.3109/09286586.2012.692006
复制
发表时间：
2012-08
影响因子：
1.8
通讯作者：
Klein R
中科院分区：
文献类型：
--
作者：
Hirai FE;Tielsch JM;Klein BE;Klein R
我们的目的是调查25年及以上1型糖尿病患者中抑郁症患者的比例及其与糖尿病视网膜病变和视力损害的关系。这是一项对威斯康星州糖尿病视网膜病变流行病学研究人群队列25年随访的横断面分析。检查遵循标准化方案，包括临床和眼科评估以及评估当前和过去病史、药物使用和吸烟情况的问卷调查。对所有参与者进行流行病学研究中心抑郁量表（CES-D）。抑郁症定义为使用抗抑郁药或CES-D评分≥16。共有484人被纳入分析。抑郁比例为37.8%（95%可信区间33.4 ~ 42.3%）。在糖尿病视网膜病变和视力障碍较严重的人群中，抑郁症患者的比例较高。然而，在多变量分析中控制其他因素时，这些关联在统计上并不显著。在这个队列中，长期1型糖尿病患者的糖尿病视网膜病变严重程度和视力与抑郁症没有横断面相关性。
Our aim was to investigate the proportion of individuals with depression and its association with diabetic retinopathy and visual impairment in a cohort with 25 or more years of type 1 diabetes. This was a cross-sectional analysis at the 25-year follow-up of the population-based cohort of the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Examinations followed standardized protocols and included clinical and ophthalmic evaluations and questionnaires to assess current and past medical history, use of medications, and cigarette smoking. The Center for Epidemiologic Studies Depression Scale (CES-D) was administered to all participants. Depression was defined as use of antidepressant or CES-D score ≥16. A total of 484 individuals were included in the analysis. The proportion of depression was 37.8% (95% confidence interval 33.4–42.3%). A higher proportion of individuals with depression was observed among those with more severe diabetic retinopathy and visual impairment. However these associations were not statistically significant while controlling for other factors in the multivariable analyses. Diabetic retinopathy severity and visual acuity in persons with long duration of type 1 diabetes were not cross-sectionally associated with depression in this cohort.