Comparative Effects of Physical Exercise and Other Behavioral Interventions on Functional Status Outcomes in Mild Cognitive Impairment.
Comparative Effects of Physical Exercise and Other Behavioral Interventions on Functional Status Outcomes in Mild Cognitive Impairment.
复制标题
体育锻炼和其他行为干预对轻度认知障碍功能状态结果的比较效果
DOI：
10.1017/s1355617721000485
复制
发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Smith GE
中科院分区：
文献类型：
--
作者：
Shandera-Ochsner AL;Chandler MJ;Locke DE;Ball CT;Crook JE;Phatak VS;Smith GE
对于轻度认知障碍（MCI）患者，生活方式的改变可能促进功能稳定，减轻疾病严重程度，并改善诸如生活质量等健康状况。我们对一项较大的比较有效性研究进行了当前分析，评估了作为梅奥诊所健康行动促进思维独立（HABIT）项目一部分的生活方式改变的哪些具体组合，有助于在18个月内使MCI患者的功能衰退最小。
我们致力于将基于证据的干预措施相互比较，而不是与无治疗对照组进行比较。干预措施是五种行为治疗方法，（计算机化认知训练（CCT）、瑜伽、记忆支持系统训练（MSS）、同伴支持小组和健康教育），每种方法都在一个基于小组的项目中提供给患有MCI的患者（pwMCI）及其照顾伙伴。为了比较干预措施，我们在每个小组课程中随机不提供5种HABIT®干预措施中的1种。我们进行了24个小组课程，每个课程有8到20对pwMCI - 伙伴组合。
根据FAQ和CDR的测量，不进行瑜伽练习导致功能能力下降最严重。此外，记忆补偿（日历）训练和认知练习似乎与更好的功能结果有关联（中等效应量）。不进行支持小组或健康教育似乎对18个月时的功能影响很小。
总体而言，这些结果进一步丰富了越来越多的文献资料，即体育锻炼在改善包括神经退行性疾病在内的许多疾病的结果方面可以发挥重要且持久的作用。
Lifestyle modifications for those with Mild Cognitive Impairment (MCI) may promote functional stability, lesson disease severity, and improve well-being outcomes such as quality of life. The current analysis of our larger comparative effectiveness study evaluated which specific combinations of lifestyle modifications offered as part of the Mayo Clinic Healthy Action to Benefit Independence in Thinking (HABIT) program contributed to the least functional decline in people with MCI over 18 months. We undertook to compare evidence based interventions with one another rather than to a no-treatment control group. The interventions were five behavioral treatments, (computerized cognitive training (CCT), yoga, memory support system training (MSS), peer support group, and wellness education), each delivered to both with pwMCI and care partners, in a group based program. To compare interventions, we randomly withheld 1 of the 5 HABIT® interventions in each of the group sessions. We conducted 24 group sessions with between and 8 to 20 pwMCI-partner dyads in a session. Withholding yoga led to the greatest declines in functional ability as measured by the FAQ and CDR. In addition, memory compensation (calendar) training and cognitive exercise appeared to have associations (moderate effect sizes) with better functional outcomes. Withholding support group or wellness education appeared to have little effect on functioning at 18 months. Overall, these results add to the growing literature that physical exercise can play a significant and lasting role in modifying outcomes in a host of medical conditions, including neurodegenerative diseases.