Protective and opsonic activities of a native, pH 4.25 intravenous immunoglobulin G preparation against common bacterial pathogens.
Protective and opsonic activities of a native, pH 4.25 intravenous immunoglobulin G preparation against common bacterial pathogens.
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天然 pH 4.25 静脉注射免疫球蛋白 G 制剂对常见细菌病原体的保护和调理活性。
DOI：
10.1093/clinids/8.supplement_4.s396
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Bathras,JM
中科院分区：
文献类型：
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作者：
Hill,HR;Bathras,JM
将一种pH为4.25的天然免疫球蛋白G （IGIV pH为4.25）与一种标准的pH为6.8的还原和烷基化免疫球蛋白G （IGIV- r / a pH为6.8）和一种pH为5.25的还原和烷基化免疫球蛋白G （IGIV- r / a pH为5.25）的体外抗多种常见细菌病原体的活性进行了比较。在大多数情况下，pH为4.25的IGIV抗体滴度等于或超过pH为6.8的IGIV- r /A抗体滴度；IGIV-R/A pH 5.25通常具有中等水平的活性。pH为4.25的IGIV对新生大鼠大肠杆菌模型的保护作用也高于pH为6.8的IGIV- r / a。因此，新的IGIV pH 4.25的功能活性明显等于或超过标准还原和烷基化制剂。
The in vitro opsonic activity of a native, pH 4.25 immunoglobulin G preparation modified for intravenous use (IGIV pH 4.25) was compared with the activities of a standard reduced and alkylated, pH 6.8 preparation (IGIV-R/A pH 6.8)and a reduced and alkylated, pH 5.25 preparation (IGIV-R/A pH 5.25) against a variety of common bacterial pathogens. In most instances the opsonic titers of IGIV pH 4.25 equaled or exceeded that of IGIV-R/A pH 6.8; IGIV-R/A pH 5.25 usually had an intermediate level of activity. The protective activity of IGIV pH 4.25 againstEscherichia coliin a neonatal rat model was also greater than that of IGIV-R/A pH 6.8. Thus, the functional activity of the new IGIV pH 4.25 apparently equals or exceedsthat of standard reduced and alkylated preparations.