PipeAlign: a new toolkit for protein family analysis
PipeAlign: a new toolkit for protein family analysis
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DOI：
10.1093/nar/gkg518
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发表时间：
2003-07-01
影响因子：
14.9
通讯作者：
Poch, O
中科院分区：
文献类型：
--
作者：
Plewniak, F;Bianchetti, L;Poch, O
PipeAlign 是一种蛋白质家族分析工具，集成了从在蛋白质和 3D 结构数据库中搜索序列同源物到定义亚家族内部和亚家族之间的层次关系的五步过程。完整的自动管道将单个序列或一组序列作为输入，并构建高质量、经过验证的 MACS（完整序列的多重比对），其中序列被聚类成潜在的功能子组。对于更有经验的用户，PipeAlign 服务器还提供了许多选项来仅运行一部分分析，并可以修改每个软件模块的默认参数。例如，用户可以选择输入现有的多序列比对，以进行序列的细化、验证和后续聚类。目的是提供一个交互式工作台，用于蛋白质家族的验证、整合和呈现，不仅在序列水平上，而且在结构和功能水平上。 PipeAlign 可在 http://igbmc.u-strasbg.fr/PipeAlign/ 上获取。
PipeAlign is a protein family analysis tool integrating a five step process ranging from the search for sequence homologues in protein and 3D structure databases to the definition of the hierarchical relationships within and between subfamilies. The complete, automatic pipeline takes a single sequence or a set of sequences as input and constructs a high-quality, validated MACS (multiple alignment of complete sequences) in which sequences are clustered into potential functional subgroups. For the more experienced user, the PipeAlign server also provides numerous options to run only a part of the analysis, with the possibility to modify the default parameters of each software module. For example, the user can choose to enter an existing multiple sequence alignment for refinement, validation and subsequent clustering of the sequences. The aim is to provide an interactive workbench for the validation, integration and presentation of a protein family, not only at the sequence level, but also at the structural and functional levels. PipeAlign is available at http://igbmc.u-strasbg.fr/PipeAlign/.