Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas™)
Myocardial perfusion quantitation with 15O-labelled water PET: high reproducibility of the new cardiac analysis software (Carimas™)
复制标题
DOI：
10.1007/s00259-009-1143-8
复制
发表时间：
2009-10-01
影响因子：
9.1
通讯作者：
Knuuti, Juhani
中科院分区：
文献类型：
--
作者：
Nesterov, Sergey V.;Han, Chunlei;Knuuti, Juhani
目的Carimas（TM）（心脏图像分析系统）是图尔库PET中心开发的一种新软件包，用于使用多种示踪剂对心脏进行定量PET研究。本研究的目的是评估结果的再现性包提供心肌灌注（MP）定量使用（15）O-标记water.Methods四个观察员与不同层次的经验，在核医学独立分析了20 MP的研究（10休息流：“休息”，10腺苷诱导的充血：“压力”）。每项研究分析两次。将重复测量的线性混合模型拟合到数据中，以计算组内相关系数（ICC）、重复测量之间的差异（观察者内差异）和观察者之间的差异（观察者间差异）。此外，计算Pearson相关系数（r）并绘制Bland-Altman图。在全球、区域和分段水平上评估MP的再现性。结果对于有经验的观察者，各节段的Pearson相关系数在静息时为0.974，在负荷时为0.978重复性系数分别为0.145 ml/g/min（平均值的15.5%）和0.389 ml/g/min（平均值的14.9%）。ICC反映了非常好的整体再现性。观察者内和观察者间的差异很小，压力下经验最丰富和经验最少的观察者之间的差异为8.5%。与有创性血管造影相比，心肌灌注定量的临床准确性非常好（阳性预测值91%，阴性预测值88%）。结论Carimas（TM）15 O标记水PET心肌灌注定量具有较高的重复性。结果支持稳健分析的可行性和良好的临床准确性。
Purpose Carimas (TM) (Cardiac Image Analysis System) is a new software package developed at the Turku PET Centre for the quantitation of PET studies of the heart with a broad range of tracers. The goal of this study was to assess the reproducibility of results the package provides for myocardial perfusion (MP) quantitation using (15)O-labelled water.Methods Four observers with various levels of experience in nuclear medicine independently analysed 20 MP studies (10 rest flow: "rest", 10 adenosine-induced hyperaemia: "stress"). Each study was analysed twice. The linear mixed model for repeated measures was fitted to the data to calculate intraclass correlation coefficients (ICC), differences between the repeats (the intraobserver differences) and differences between the observers (the interobserver differences). Also, Pearson correlation coefficients (r) were calculated and Bland-Altman plots were drawn. The reproducibility of MP was assessed on global, regional and segmental levels. Thereafter, this analysis was applied in 48 consecutive clinical patients with suspected coronary heart disease (CHD).Results For the experienced observer the Pearson r for all segments was 0.974 at rest and 0.978 at stress (p< 0.0001), and the repeatability coefficients were 0.145 ml/g per min (15.5% of the average) and 0.389 ml/g per min (14.9%), correspondingly. The ICC reflected very good overall reproducibility. The intraobserver and interobserver differences were small, and the difference between the most and the least experienced observers at stress was 8.5% for the global MP. The clinical accuracy of the perfusion in the detection of CHD was excellent (positive predictive value 91% and negative predictive value 88%) against invasive angiography.Conclusion The results demonstrate high reproducibility of myocardial perfusion quantitation with (15)O-labelled water PET using Carimas (TM). The results support the feasibility of robust analysis and good clinical accuracy.