Regulation of human gonadotropins. X. Episodic fluctuation of LH during the menstrual cycle.
Regulation of human gonadotropins. X. Episodic fluctuation of LH during the menstrual cycle.
复制标题
人类促性腺激素的调节。
DOI：
10.1210/jcem-33-6-962
复制
发表时间：
1971
期刊：
影响因子：
--
通讯作者：
R. Jaffe
中科院分区：
文献类型：
--
作者：
A. Midgley;R. Jaffe
为了确定月经周期中 LH（黄体生成素）的周期性波动，密歇根大学（安娜堡，1971 年）对 7 名女性（21-28 岁）在月经周期不同阶段连续每小时采集的 49 个样本进行了放射免疫分析。在每种情况下，每小时分析表明 LH 以及可能的 FSH（卵泡刺激素）的血清浓度维持在一系列不同大小的峰值。采样间隔的长度妨碍了对峰值频率的精确确定，峰值出现的频率大约为 2 1/2 小时。最大的 LH 峰值记录在周期中期 LH 主峰的上升和下降阶段以及周期的早期黄体期。卵泡期产生最小的 LH 峰值。这些观察结果支持这样的假设：LH 和 FSH 的血清浓度通过短暂的释放期和随后的很少或不释放期来维持。 LH 和 FSH 的相应变化表明它们是同时释放的，并且可能包含在同一细胞内。为了维持血液浓度，同时释放的 LH 的相对量应大于 FSH 的相对量，因为后者的半衰期较长。可能还涉及其他因素，因为在月经周期的不同阶段可以观察到 LH/FSH 的比率差异很大。建议准确分析 LH 和 FSH 浓度需要至少每隔半小时采样一次，这对于 ACTH 是必要的。
In order to determine the episodic fluctuation of LH (luteinizing hormone) during the menstrual cycle, the University of Michigan (Ann Arbor, 1971) subjected 49 samples, obtained at consecutive hourly intervals from seven women (ages 21-28) at different stages of the menstrual cycle, to radioimmunoassay. In each case, hourly analysis indicated that serum concentrations of LH, and possibly FSH (follicle stimulating hormone), are maintained as a series of peaks of varying magnitude. The length of the sampling interval prevented an exact determination of the frequency of the peaks which appeared to occur at approximately 2 1/2 hour intervals. The largest LH peaks were recorded during the ascending and descending phases of the major peak of LH at midcycle and during the early luteal phase of the cycle. The follicular phase produced the smallest LH peaks. These observations support the hypothesis that serum concentrations of LH and FSH are maintained by brief periods of release followed by periods of little or no release. Corresponding changes in LH and FSH suggest that they are released simultaneously and may be contained within the same cell. To maintain blood concentrations, the relative amount of simultaneously released LH should be greater than that of FSH since the latter has a longer half-life. Additional factors may be involved, since widely different ratios of LH/FSH can be observed at various phases of the menstrual cycle. It is suggested that accurate analysis LH and FSH concentrations requires sampling at least at half-hour intervals as is necessary for ACTH.