Application of ultrasound energy as a new drug delivery system
Application of ultrasound energy as a new drug delivery system
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DOI：
10.1143/jjap.38.3014
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发表时间：
1999-05-01
期刊：
影响因子：
--
通讯作者：
Tachibana, S
中科院分区：
文献类型：
--
作者：
Tachibana, K;Tachibana, S
超声在过去的三十年中一直被用作医学诊断成像的模式。近年来，利用非热超声能量靶向或控制药物释放的研究报道很多，这一治疗性超声与药物结合的新概念引起了医学界的广泛关注。超声能量可以增强溶栓药物如尿激酶的作用。目前正在开发治疗性超声导管用于治疗心血管疾病。在透皮药物贴片中植入超声换能器的装置也正在评估通过皮肤输送胰岛素的可能性。利用超声能量化学活化药物治疗癌症是近年来发展起来的又一新领域，被称为声动力学疗法。超声应用的各种例子正在调查中，这可能会导致革命性的药物输送系统在未来。
Ultrasound has been in use for the last three decades as a modality for diagnostic imaging in medicine. Recently, there have been numerous reports on the application of nonthermal ultrasound energy for targeting or controlling drug release, This new concept of therapeutic ultrasound combined with drugs has led to much excitement in various medical fields. Ultrasound energy can enhance the effects of thrombolytic agents such as urokinase. Therapeutic ultrasound catheters are currently being developed for treatment of cardiovascular diseases. Devices with ultrasound transducers implanted in transdermal drug patches are also being evaluated for possible delivery of insulin through the skin. Chemical activation of drugs by ultrasound energy for treatment of cancers is another new field recently termed "Sonodynamic Therapy". Various examples of ultrasound application are under investigation which could lead to revolutionary drug delivery systems in the future.