Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex
Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex
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DOI：
10.1128/aac.00159-19
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发表时间：
2019-06-01
影响因子：
4.9
通讯作者：
Koser, Claudio U.
中科院分区：
文献类型：
--
作者：
Loiseau, Chloe;Brites, Daniela;Koser, Claudio U.
我们使用894个遗传多样的结核分枝杆菌复合群（MTBC）基因组，通过计算机模拟海恩生命科学GenoType MTBC检测试剂盒区分结核病病原体的能力。在这里，我们提出了一个修订的解释，以反映其优势（例如，它可以区分对吡嗪酰胺本身没有抗性的卡氏分枝杆菌的一些菌株和牛分枝杆菌的变体）和局限性（例如，米分枝杆菌不能与非洲分枝杆菌区分）。
Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum).