Long-term effects of short-lasting early local inflammatory insult
Long-term effects of short-lasting early local inflammatory insult
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DOI：
10.1097/00001756-200102120-00042
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发表时间：
2001-02-12
期刊：
影响因子：
1.7
通讯作者：
Ren, K
中科院分区：
文献类型：
--
作者：
Lidow, MS;Song, ZM;Ren, K
我们检查了向新生 (PO) 幼鼠的后爪注射 0.25% 角叉菜胶 (1 mul/g) 产生的短期（类似于 24 小时）炎症损伤的长期影响。在 P60 时，经历过这种早期炎症损伤的动物表现出对受影响爪子的有害刺激的退缩反应的显着改变。此外，在没有持续炎症的情况下，这种经历增加了热刺激的戒断潜伏期和机械刺激的戒断阈值。然而，在持续存在 CPA 诱导的炎症的情况下，同样的早期经历降低了这些对有害刺激反应的参数。这些数据表明，早期炎症损伤可能对涉及短暂疼痛敏感性和炎症引起的痛觉过敏的伤害性回路的各个方面产生不同的影响。 NeuroReport 12:399-403 (C) 2001 Lippincott Williams & Wilkins。
We examined the long-term effects of a short-lasting (similar to 24 h) inflammatory insult generated by injections of 0.25% carrageenan (1 mul/g) into the hindpaws of newborn (PO) rat pups. At P60 animals which experienced this early inflammatory insult showed significant alterations in the withdrawal responses to noxious stimulation of the affected paws. Furthermore, in the absence of ongoing inflammation, the withdrawal latencies to heat stimulation and withdrawal thresholds to mechanical stimulation were increased by such experience. In the presence of ongoing CPA-induced inflammation, however, the same early experience decreased these parameters of response to noxious stimulation. These data suggest that early inflammatory insult may differentially affect the aspects-of nociceptive circuitry involved in transient pain sensitivity and in inflammation-induced hyperalgesia. NeuroReport 12:399-403 (C) 2001 Lippincott Williams & Wilkins.