Association between dysfunction of autonomic nervous system activity and mortality in schizophrenia
Association between dysfunction of autonomic nervous system activity and mortality in schizophrenia
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DOI：
10.1016/j.comppsych.2018.08.002
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发表时间：
2018-10-01
影响因子：
7.3
通讯作者：
Hirayasu, Yoshio
中科院分区：
文献类型：
--
作者：
Hattori, Saki;Suda, Akira;Hirayasu, Yoshio
背景：精神分裂症患者的死亡风险高于一般人群。此外，精神分裂症患者的自主神经系统（ANS）活动比一般人群更低，功能更失调。尽管如此，ANS功能障碍与精神分裂症死亡率之间的关系尚不清楚。本研究的目的是调查ANS活动和精神分裂症死亡率之间的关联，并评估心率变异性的预测值为长期survival.Methods：本研究涉及的样本人群组成的59个日本精神分裂症住院患者60和70岁之间的10年随访2007年至2016年。2007年采用心率变异性评价所有患者的ANS活动。结果：53例患者因在随访期间住院，可获得随访。在这些患者中，11例在随访期间死亡。他们的平均死亡年龄为70.55 ± 3.45岁。非幸存者的副交感神经活性显着低于幸存者，和多元Logistic回归分析显示死亡和副交感神经activity.Conclusion之间的显着关联：我们建议，副交感神经活性下降可能与10年的所有原因死亡率在老年精神分裂症患者。(C)2018爱思唯尔公司All rights reserved.
Background: Patients with schizophrenia have a higher mortality risk than the general population. Additionally, the autonomic nervous system (ANS) activity of patients with schizophrenia is lower and more dysfunctional than that of the general population. Nonetheless, the association between ANS dysfunction and mortality in schizophrenia is unclear. The aim of this study was to investigate the association between ANS activity and mortality in schizophrenia and to evaluate the predictive values of heart rate variability for long-term survival.Methods: This study involves the 10-year follow-up of a sample population consisting of 59 Japanese inpatients with schizophrenia between 60 and 70 years of age from 2007 to 2016. The ANS activity of all patients was evaluated using heart rate variability in 2007.Results: Fifty-three participants could be followed up because they stayed in the hospital during the follow-up period. Of these patients, 11 died during follow-up. Their mean age at death was 70.55 +/- 3.45 years. The parasympathetic activity of nonsurvivors was significantly lower than that of survivors, and multiple logistic regression analysis showed a significant association between death and parasympathetic activity.Conclusion: We suggest that decreased parasympathetic activity could be associated with 10-year all-cause mortality in older schizophrenic patients. (C) 2018 Elsevier Inc. All rights reserved.