CLONING OF B7-2 - A CTLA-4 COUNTER-RECEPTOR THAT COSTIMULATES HUMAN T-CELL PROLIFERATION
CLONING OF B7-2 - A CTLA-4 COUNTER-RECEPTOR THAT COSTIMULATES HUMAN T-CELL PROLIFERATION
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DOI：
10.1126/science.7694363
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发表时间：
1993-11-05
期刊：
影响因子：
56.9
通讯作者：
NADLER, LM
中科院分区：
文献类型：
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作者：
FREEMAN, GJ;GRIBBEN, JG;NADLER, LM
虽然抗原向T细胞受体的呈递对于免疫应答的启动是必需的，但抗原呈递细胞上表达的其他分子会传递重要的共刺激信号。在没有共刺激的情况下，T细胞活化会导致T细胞无反应性。B7 - 1蛋白是一种共刺激分子，它通过使用CD28和CTLA - 4的通路（以下称为CD28通路）进行信号传导来调节白细胞介素 - 2（IL - 2）的分泌。我们已经克隆了CD28和CTLA - 4的一个反受体，称为B7 - 2。尽管与B7 - 1只有26%的同一性，B7 - 2也能共刺激IL - 2的产生和T细胞增殖。与B7 - 1不同，B7 - 2信使RNA在未受刺激的B细胞中组成性表达。B7 - 2很可能提供了一个关键的早期共刺激信号，该信号决定了T细胞是会促进免疫应答还是变得无反应。
Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on antigen-presenting cells deliver essential costimulatory signals. T cell activation, in the absence of costimulation, results in T cell anergy. The B7-1 protein is a costimulator molecule that regulates interleukin-2 (IL-2) secretion by signaling through the pathway that uses CD28 and CTLA-4 (hereafter referred to as the CD28 pathway). We have cloned a counter-receptor of CD28 and CTLA-4, termed B7-2. Although only 26 percent identical to B7-1, B7-2 also costimulates IL-2 production and T cell proliferation. Unlike B7-1, B7-2 messenger RNA is constitutively expressed in unstimulated B cells. It is likely that B7-2 provides a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic.