Linear IgA disease (LAD): immunoglobulin deposition in oral and colonic lesions.
Linear IgA disease (LAD): immunoglobulin deposition in oral and colonic lesions.
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线性 IgA 疾病 (LAD)：口腔和结肠病变中的免疫球蛋白沉积。
DOI：
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发表时间：
1995
影响因子：
3.3
通讯作者：
K. Mckenna
中科院分区：
文献类型：
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作者：
C. Cowan;P. Lamey;M. Walsh;S. Irwin;G. Allen;K. Mckenna
两例成人线性伊加疾病（LAD）与口腔和结肠的参与。两名患者的口腔检查结果均为广泛疼痛性溃疡，持续2 - 3个月，诊断通过活检和直接免疫荧光证实。在这两种情况下，结肠症状先于口腔症状，并进行了一些调查，包括常规组织学检查，这表明淋巴细胞性结肠炎或克罗恩病。免疫荧光研究显示线性伊加沉积局限于远端结肠。这些病例强调大肠受累可能是线性伊加疾病的一个特征，并首次证明该部位存在伊加沉积。
Two cases of adult linear IgA disease (LAD) with oral and colonic involvement are presented. Oral findings, for both patients, were of widespread painful ulceration present for two to three months and diagnosis was confirmed by biopsy and direct immunofluorescence. Colonic symptoms preceded oral symptoms in both cases and a number of investigations were undertaken, including routine histological examination, which suggested either lymphocytic colitis or Crohn's disease. Immunofluorescence studies showed linear IgA deposition confined to the distal colon. These cases highlight that large bowel involvement can be a feature of linear IgA disease and for the first time demonstrate IgA deposition at that site.