Vertebrate Cryptochromes are Vestigial Flavoproteins.
Vertebrate Cryptochromes are Vestigial Flavoproteins.
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DOI：
10.1038/srep44906
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发表时间：
2017-03-20
影响因子：
4.6
通讯作者：
Scrutton NS
中科院分区：
文献类型：
--
作者：
Kutta RJ;Archipowa N;Johannissen LO;Jones AR;Scrutton NS
所有隐花色素目前都被归类为黄素蛋白。在动物中，它们最好的描述是作为生物钟的组成部分。这种昼夜节律功能是可变的，并且可以是光依赖性的或非依赖性的;这种差异的分子起源是未知的。I型动物隐花色素是将生物体的生物钟带入其环境的光感受器，而II型（包括哺乳动物）以不依赖于光的方式调节昼夜节律。在这里，我们发现，与I型相反，II型动物隐花色素缺乏结构特征，以安全地结合光敏黄素辅因子。我们提供了一个不同的昼夜节律的作用，不同的动物隐花色素的分子基础，这也有显着的影响II型隐花色素在动物photomagnetoreception的假定作用。
All cryptochromes are currently classified as flavoproteins. In animals their best-described role is as components of the circadian clock. This circadian function is variable, and can be either light-dependent or -independent; the molecular origin of this difference is unknown. Type I animal cryptochromes are photoreceptors that entrain an organism’s clock to its environment, whereas Type II (including mammals) regulate circadian timing in a light-independent manner. Here, we reveal that, in contrast to Type I, Type II animal cryptochromes lack the structural features to securely bind the photoactive flavin cofactor. We provide a molecular basis for the distinct circadian roles of different animal cryptochromes, which also has significant implications for the putative role of Type II cryptochromes in animal photomagnetoreception.