Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration
Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration
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DOI：
10.1093/ajcn/83.4.880
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发表时间：
2006-04-01
影响因子：
7.1
通讯作者：
Taylor, A
中科院分区：
文献类型：
--
作者：
Chiu, CJ;Hubbard, LD;Taylor, A
背景资料：一些饮食因素与年龄相关性黄斑病变（ARM）有关，ARM是年龄相关性黄斑变性的早期形式，有理由认为饮食碳水化合物可能在ARM的发展中发挥作用。目的：本研究的目的是检查饮食碳水化合物质量（通过饮食血糖指数（GI）或总碳水化合物摄入量测量）与ARM之间的关系。设计：来自护士健康研究的526名波士顿地区参与者的1036只眼睛没有先前的ARM诊断被纳入本研究。ARM的存在和程度通过眼相关眼病研究系统进行分类。长期的饮食信息是基于在评估ARM之前的10年期间收集的平均4份食物频率问卷的数据。以眼睛为分析单位，我们使用了一种广义估计方法进行logistic回归，以一种解释同一受试者的2只眼睛之间缺乏独立性的方式来估计ARM的比值比。多变量校正后，饮食GI与ARM（特别是视网膜色素异常）相关，而总碳水化合物摄入量则无关。ARM处于饮食GI最高三分位数（>= 77.0）与最低三分位数（< 74.6）的比值比为2.7]（95%CI：1.24，5.93;趋势P = 0.01）。无论是饮食GI还是总碳水化合物摄入量与玻璃膜疣。结论：我们的研究结果表明，饮食GI可能是一个独立的危险因素为ARM。
Background: Several dietary factors have been linked to agerelated maculopathy (ARM), the early form of age-related macular degeneration, and there is reason to think that dietary carbohydrate may play a role in the development of ARM. Objective: The purpose of the present study was to examine the relation between dietary carbohydrate quality, as measured by dietary glycemic index (GI) or total carbohydrate intake, and ARM.Design: From the Nurses' Health Study, 1036 eyes from 526 Boston-area participants without a previous ARM diagnosis were included in the present study. The presence and degree of ARM were classified by the Age-Related Eye Diseases Study system. Longterm dietary information was based on data from an average of 4 food-frequency questionnaires collected over a 10-y period before the assessment of ARM. With eyes as the unit of analysis, we used a generalized estimating approach to logistic regression to estimate the odds ratios for ARM in a manner that accounted for the lack of independence between the 2 eyes from the same subject.Results: After multivariate adjustment, dietary GI was related to ARM (specifically to retinal pigmentary abnormalities), whereas total carbohydrate intake was not. The odds ratio for ARM being in the highest tertile of dietary GI (>= 77.0) versus the lowest (< 74.6) was 2.7](95%CI: 1.24, 5.93; P for trend= 0.01). Neither dietary GI nor total carbohydrate intake was related to drusen.Conclusion: Our results suggest that dietary GI may be an independent risk factor for ARM.