Opinion - Why is cancer drug discovery so difficult?

Opinion - Why is cancer drug discovery so difficult?
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DOI:
10.1038/nrd2155
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发表时间:
2007-02-01
影响因子:
120.1
通讯作者:
Lengauer, Christoph
Lengauer, Christoph
中科院分区:
医学1区
文献类型:
--
作者:
Kamb, Alexander;Wee, Susan;Lengauer, Christoph

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Thirty-five years after the 'war on cancer' was declared, the discovery of anticancer drugs remains a highly challenging endeavour. Here, we consider the factors responsible, such as tumour heterogeneity, and suggest strategies to improve the chances of short-term success in the development of novel anticancer drugs.