Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene-Ferric oxide.
Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene-Ferric oxide.
复制标题
维生素 A 缺乏或苯并[a]芘-氧化铁引起的仓鼠气管上皮鳞状化生的组织发生。
DOI：
10.1093/jnci/48.3.743
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
U. Saffiotti
中科院分区：
文献类型：
--
作者：
C. Harris;M. Sporn;D. Kaufman;J. M. Smith;F. Jackson;U. Saffiotti
在仓鼠气管上皮中，维生素A缺乏和多次气管内注入苯并[A]芘氧化铁均可引起鳞状皮化生。光镜下，维生素A缺乏引起的无细胞异型性的鳞状化生与致癌物引起的鳞状化生在形态上相似。然而，在超微结构水平上观察到显著差异。基底膜缺陷、细胞核增大、胞浆内陷、核仁多形性局限于苯并[a]芘氧化铁诱导的鳞状化生。
In the hamster tracheal epithelium, both vitamin A deficiency and multiple intratracheal instillations of benzo[a]pyrene-ferric oxide caused squamous metaplasia. By light microscopy, squamous metaplasia without cell atypia caused by vitamin A deficiency is morphologically similar to that caused by carcinogen administration. However, significant differences at the ultrastructural level were observed. Defects in the basement membrane, enlarged nuclei with cytoplasmic invaginations, and pleomorphic nucleoli were restricted to squamous metaplasia induced by benzo[a]pyrene-ferric oxide.