SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells.
SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells.
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SLC7A5作为CRKL调节的下游靶点在胃癌SGC-7901细胞转移过程中发挥作用
DOI：
10.1371/journal.pone.0166147
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Wang J;Fei X;Wu W;Chen X;Su L;Zhu Z;Zhou Y
SLC7A5, who is also named LAT-1, has been validated as a promoter regulated by miRNA-126 in our previous research for gastric cancer cells. However, the mechanisms driving SLC7A5 to affect the bio-function of gastric cancer cells are unclear, remaining us lots of to elucidate. The aim of this study is to investigate the regulating effect of CRKL, one of the critical genes involving with gastric cancer progression, on SLC7A5 expression. By studying the gastric cancer cell lines and clinical pathological specimens, we found that the expression of SLC7A5 was significantly correlated to CRKL. By depleting CRKL in gastric cancer SGC-7901 cells, the SLC7A5 expression was impaired, and the invasion and migration of SGC-7901 cells were suppressed. Ectopic expression of SLC7A5 could drastically rescue the phenotypes induced by CRKL depletion in this study. Accordingly, we conclude that SLC7A5 functions as a promoter in gastric cancer metastasis, and CRKL could be one of its regulators modulating the expression of SLC7A5 and consequentially affect the metastatic feature of SGC-7901 cells. The findings in this study indicate a regulation relationship between CRKL and SLC7A5, and provide useful evidence for gastric cancer therapeutic strategies.
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影响因子：
4.6
作者：
Ungewiss C;Rizvi ZH;Roybal JD;Peng DH;Gold KA;Shin DH;Creighton CJ;Gibbons DL
通讯作者：
Gibbons DL
影响因子：
4.3
作者：
Russo, Francesco;Linsalata, Michele;Orlando, Antonella
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Orlando, Antonella
影响因子：
3.7
作者：
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Los M
影响因子：
5.1
作者：
Wang, Junqing;Chen, Xuehua;Zhu, Zhenggang
通讯作者：
Zhu, Zhenggang
影响因子：
3
作者：
Galluccio, Michele;Pingitore, Piero;Indiveri, Cesare
通讯作者：
Indiveri, Cesare