Evidence that molecules on the surface of one cell can adhere to the oligosaccharide portion of gangliosides on the surface of another cell.
Evidence that molecules on the surface of one cell can adhere to the oligosaccharide portion of gangliosides on the surface of another cell.
复制标题
有证据表明一个细胞表面的分子可以粘附到另一个细胞表面的神经节苷脂的寡糖部分。
DOI：
10.1159/000109414
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Schengrund,CL
中科院分区：
文献类型：
--
作者：
Schengrund,CL
尽管已有大量关于神经节苷脂在神经元发育中的可能作用及其功效或缺乏功效的报道，作为治疗神经元损伤的可能治疗剂，但它们诱导特定细胞效应的分子机制尚不清楚。这篇综述提供了细胞表面分子存在的证据，该分子能够粘附到特定神经节苷脂的寡糖部分，并描述了他们的研究所采用的方法。这种细胞表面分子的鉴定允许这样的假设：神经节苷脂的寡糖部分与其细胞表面受体的结合负责启动导致细胞行为改变的细胞内反应。
While there have been numerous reports concerning the possible role(s) of gangliosides in neuronal development and their efficacy, or lack thereof, as possible therapeutic agents for the treatment of neuronal injury, the molecular mechanisms by which they induce specific cellular effects are not well understood. This review presents evidence for the existence of cell surface molecules able to adhere to the oligosaccharide portion of specific gangliosides and describes methods employed for their study. The identification of such cell surface molecules permits the hypothesis that the binding of the oligosaccharide portion of the ganglioside by its cell surface receptor is responsible for initiating the intracellular reactions that lead to modified cell behavior.