Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)2-catalyzed Suzuki-coupling reaction
Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)2-catalyzed Suzuki-coupling reaction
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DOI：
10.1016/s0040-4039(01)00966-2
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发表时间：
2001-07-30
影响因子：
1.8
通讯作者：
Wu, QQ
中科院分区：
文献类型：
--
作者：
Ma, DW;Wu, QQ
在没有膦配体的条件下，以氟化钾为碱，通过Pd(OAc)(2)催化的Suzuki偶联反应，合成了蛋白酶体抑制剂TMC-95的联芳基。(C)2001爱思唯尔科学有限公司。保留所有权利。
The biaryl moiety of proteasome inhibitors TMC-95 was synthesized via a Pd(OAc)(2)-catalyzed Suzuki-coupling reaction of 7-iodoisatin and a tyrosine-derived arylboronic acid in the absence of phosphine ligands using potassium fluoride as a base. (C) 2001 Elsevier Science Ltd. All rights reserved.