Sirtuins, a promising target in slowing down the ageing process.
Sirtuins, a promising target in slowing down the ageing process.
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DOI：
10.1007/s10522-017-9685-9
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发表时间：
2017-08
期刊：
影响因子：
4.5
通讯作者：
Bielak-Zmijewska A
中科院分区：
文献类型：
--
作者：
Grabowska W;Sikora E;Bielak-Zmijewska A
衰老是一个可塑的过程，可以通过一些生物医学方法或药剂来成功调节。通过这种方式，可以延迟甚至预防一些与年龄相关的病症。有一些明确的干预措施可以在动物模型甚至人类研究中产生有希望的结果，从而延长寿命或改善健康状况。抗衰老方法最有希望的目标之一是属于沉默调节蛋白家族的蛋白质。 Sirtuins 最初被发现是酵母中的转录抑制因子，然而，现在已知它们存在于细菌和真核生物（包括哺乳动物）中。在人类中，该家族由七个成员 (SIRT1-7) 组成，它们具有单 ADP 核糖基转移酶或脱乙酰酶活性。人们认为去乙酰化酶在细胞对各种应激（例如氧化应激或基因毒性应激）的反应过程中发挥着关键作用，并且对于细胞代谢至关重要。尽管一些数据对sirtuins直接参与延长人类寿命提出了质疑，但有记录表明，包括体力活动和饮食在内的正确生活方式可以通过增加sirtuins的水平来影响健康寿命。寻找去乙酰化酶激活剂是最广泛和最有力的研究课题之一。一些人把希望寄托在天然化合物上，包括姜黄素。在这篇综述中，我们总结了去乙酰化酶在抗衰老干预中的参与和有用性，并讨论了姜黄素在去乙酰化酶调节中的潜在作用。
Ageing is a plastic process and can be successfully modulated by some biomedical approaches or pharmaceutics. In this manner it is possible to delay or even prevent some age-related pathologies. There are some defined interventions, which give promising results in animal models or even in human studies, resulting in lifespan elongation or healthspan improvement. One of the most promising targets for anti-ageing approaches are proteins belonging to the sirtuin family. Sirtuins were originally discovered as transcription repressors in yeast, however, nowadays they are known to occur in bacteria and eukaryotes (including mammals). In humans the family consists of seven members (SIRT1-7) that possess either mono-ADP ribosyltransferase or deacetylase activity. It is believed that sirtuins play key role during cell response to a variety of stresses, such as oxidative or genotoxic stress and are crucial for cell metabolism. Although some data put in question direct involvement of sirtuins in extending human lifespan, it was documented that proper lifestyle including physical activity and diet can influence healthspan via increasing the level of sirtuins. The search for an activator of sirtuins is one of the most extensive and robust topic of research. Some hopes are put on natural compounds, including curcumin. In this review we summarize the involvement and usefulness of sirtuins in anti-ageing interventions and discuss the potential role of curcumin in sirtuins regulation.
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影响因子：
7.3
作者：
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