Nodlar lymphoma: An ultrastructural study of its relationship to germinal genters and a correlation of light and electron microscopic findings
Nodlar lymphoma: An ultrastructural study of its relationship to germinal genters and a correlation of light and electron microscopic findings
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结节性淋巴瘤：其与生殖细胞关系的超微结构研究以及光镜和电子显微镜检查结果的相关性
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
R. Dorfman
中科院分区：
文献类型：
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作者：
G. Levine;R. Dorfman
本研究描述了 16 例结节性淋巴瘤的超微结构发现，并将其与正常生发中心进行比较，以确定淋巴瘤可能的生发中心起源。在所有 16 例结节性淋巴瘤中均发现了长分支桥粒相关树突状网状细胞，这是生发中心的特征。仅在树突状细胞之间观察到桥粒，而在淋巴样细胞之间未观察到桥粒，并且仅在 7 例弥漫性淋巴瘤病例中观察到桥粒。构成结节性淋巴瘤的细胞与生发中心细胞具有共同的细胞学特征，例如核泡和明显的核凹痕。结节性淋巴瘤似乎与生发中心具有密切的解剖学关系，尽管本研究尚未确定它们来自这些部位的实际位置。它们由淋巴样细胞组成；我们没有证据证实结节性淋巴瘤源自树突状细胞的观点。为了确定结节性淋巴瘤中大的“组织细胞样”细胞的性质，对光镜和电子显微镜的结果进行了比较。许多这些细胞似乎代表转化的淋巴细胞而不是组织细胞。它们在所谓的混合“组织细胞”淋巴细胞淋巴瘤中比在低分化淋巴细胞淋巴瘤中数量更多，而低分化淋巴细胞淋巴瘤在其他方面在超微结构上是相似的。这项研究对结节性淋巴瘤的囊内是否存在混合淋巴细胞和组织细胞淋巴瘤提出了怀疑，并表明在被解释为低分化淋巴细胞的细胞和迄今为止被识别为组织细胞的细胞之间存在细胞学连续体。
This study describes the ultrastructural findings in 16 cases o f nodular lymphoma, and compares these with normal germinal centers in order to determine the possible germinal center origin of the lymphomas. Long branching desmosome‐associated dendritic reticulum cells, characteristic of germinal centers, were found in all 16 cases of nodular lymphoma. Desmosomes were observed only between dendritic cells and not between lymphoid cells, and they were seen in only 1 of 7 cases of diffuse lyniphoma. Cells comprising the nodular lymphomas share cytologic features, such as nuclear blebs and marked nuclear indentations, with germinal center cells. I t appears that nodular lymphomas have a close anatomical relationship to germinal centers, although their actual migin from these sites is not established by this study. They are composed ollymphoid cells; we have no evidence to confirm the view that nodular lymphomas are derived from dendritic cells. Light and electron microscopic findings have been compared in order to establish the nature of large “histiocyte‐like” cells in the nodular lymphomas. Many of these cells appear to represent transformed lymphocytes rather than histiocytes. They are more numerous in so‐called mixed “histiocytic” lymphocytic lymphomas than in poorly differentiated lymphocytic lymphomas, which otherwise are ultrastructurally similar. This study casts doubt upon the existence of a mixed lymphocytic and histiocytic lymphoma within the sliectrum of the nodular lymphomas, and indicates that a cytologic continuum exists between cells interpreted as poorly differentiated lymphocytes and those heretofore identified as histiocytes.