Long-term caloric restriction ameliorates the decline in diastolic function in humans
Long-term caloric restriction ameliorates the decline in diastolic function in humans
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DOI：
10.1016/j.jacc.2005.08.069
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发表时间：
2006-01-17
影响因子：
24
通讯作者：
Fontana, L
中科院分区：
文献类型：
--
作者：
Meyer, TE;Kovács, SJ;Fontana, L
目的研究卡路里限制(CR)是否具有心脏特异性效应，以减轻已建立的衰老相关的舒张期功能损害(DF)。背景：卡路里限制延缓了小型哺乳动物的衰老过程；然而，长期的CR对人类衰老的影响尚不清楚。在健康个体中，多普勒超声心动图已经建立了与年龄相关的DF损害的模式，而收缩功能(SF)几乎没有变化。方法对25名年龄为53+/-12岁的受试者进行了舒张期功能的评估，其中25名受试者接受CR治疗6.5+/-4.6年，25名年龄和性别匹配的对照组接受西方饮食。通过传输血流、多普勒组织成像和E波基于模型的图像处理(MBIP)对舒张期功能进行量化。结果两组间SF无差异，但CR组的标准血流动力学指标与青年组相似，而反映腔室粘弹性和僵硬程度的基于MBIP的血流衍生DF指数显著低于对照组。CR组血压、血清C反应蛋白、肿瘤坏死因子-α和转化生长因子-β(1)水平(分别为10 2+/-10/61+/-7 mm Hg，0.3/-0.3 mg/L，0.8+/-0.5pg/ml，2 9.4+/-6.9 ng/ml)显著低于西药组(13 1+/-11/83+/-6 mm Hg，1.9+/-2.8 mg/L，1.5+/-1.0pg/ml)，35.4+/-7.1 ng/ml)。结论限制热量摄入具有心脏特异性作用，可改善增龄相关的DF变化。这些对心功能的有益影响可能是通过CR对血压、全身炎症和心肌纤维化的影响而实现的。
OBJECTIVES We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF).BACKGROUND Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF).METHODS Diastolic function was assessed in 25 subjects (age 53 +/- 12 years) practicing CR for 6.5 +/- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmittal flow, Doppler tissue imaging, and model-based image processing (MBIP) of E waves. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta(1) (TGF-beta(1)) were also measured.RESULTS No difference in SF was observed between groups; however, standard transmittal Doppler flow DF indexes of the CR group were similar to those of younger individuals, and MBIP-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum CRP, TNF-a, and TGF-beta(1) levels were significantly lower in the CR group (102 +/- 10/61 +/- 7 mm Hg, 0.3 +/- 0.3 mg/l, 0.8 +/- 0.5 pg/ml, 29.4 +/- 6.9 ng/ml, respectively) compared with the Western diet group (131 +/- 11/83 +/- 6 mm Hg, 1.9 +/- 2.8 mg/l, 1.5 +/- 1.0 pg/ml, 35.4 +/- 7.1 ng/ml, respectively).CONCLUSIONS Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.