Association between central systolic blood pressure, white matter lesions in cerebral MRI and carotid atherosclerosis
Association between central systolic blood pressure, white matter lesions in cerebral MRI and carotid atherosclerosis
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DOI：
10.1038/hr.2009.121
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发表时间：
2009-10-01
影响因子：
5.4
通讯作者：
Matsumoto, Masayasu
中科院分区：
文献类型：
--
作者：
Shrestha, Isha;Takahashi, Tetsuya;Matsumoto, Masayasu
脑磁共振成像（MRI）上观察到的白色高信号（WMH）与年龄和高血压相关，提示发病机制为血管机制。中心收缩压（cSBP）与心血管疾病风险指标的相关性比肱动脉压更密切。我们试图确定cSBP是否与WMH相关，以及cSBP是否可预测脑血管疾病。在接受颈动脉超声检查的患者中进行了cSBP和增强指数（AI）的径向压平眼压测量。使用液体衰减反转恢复（FLAIR）-MRI对WMH进行回顾性评估，如脑室周围（PVH）和深部白色高信号（DWMH），并使用Fazekas量表对其进行评级。研究共纳入179例患者，94例（53%）男性和85例（47%）女性，平均年龄为66 ± 13岁。在MRI上，分别有17、74、67和21例患者的PVH等级为0、1、2和3。分别有48、69、49和13例DWMH等级为0、1、2和3。在我们研究的人群中，PVH与年龄、肱动脉SBP、cSBP和AI相关（r=0.49，0.28，0.23; P
White matter hyperintensities (WMHs) observed on cerebral magnetic resonance images (MRIs) are associated with age and hypertension, suggesting a vascular mechanism of pathogenesis. Central systolic blood pressure (cSBP) correlates more closely with measures of cardiovascular disease risk than brachial pressure. We sought to determine whether cSBP correlates with WMHs and if cSBP is predictive of cerebrovascular disease. Radial applanation tonometric measurements for cSBP and augmentation index (AI) were carried out in unselected individuals undergoing carotid ultrasound. WMHs were assessed retrospectively using fluid-attenuated inversion recovery (FLAIR)-MRIs as periventricular (PVH) and deep white matter hyperintensities (DWMH), and they were rated using the Fazekas scale. A total of 179 patients, 94 (53%) men and 85 (47%) women, with a mean age of 66 +/- 13 years were included in the study. On MRI, 17, 74, 67 and 21 patients had PVH grades 0, 1, 2 and 3, respectively. Forty-eight, 69, 49 and 13 had DWMH grades 0, 1, 2 and 3, respectively. In our study population, PVH correlated with age, brachial SBP, cSBP and AI (r=0.49, 0.28, 0.23; P