Bioactive saponins from Acacia tenuifolia from the suriname rainforest.
Bioactive saponins from Acacia tenuifolia from the suriname rainforest.
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DOI：
10.1021/np0103620
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发表时间：
2002-01
影响因子：
5.1
通讯作者：
Y. Seo;J. Hoch;M. Abdel-Kader;S. Malone;I. Derveld;H. Adams;M. C. Werkhoven;J. Wisse;S. Mamber;J. Dalton;D. Kingston
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文献类型：
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作者：
Y. Seo;J. Hoch;M. Abdel-Kader;S. Malone;I. Derveld;H. Adams;M. C. Werkhoven;J. Wisse;S. Mamber;J. Dalton;D. Kingston
使用工程酵母菌株1138、1140、1353和Sc 7作为生物测定工具，对细叶金合欢的MeOH提取物进行生物测定引导的分级分离，导致分离出三种新的皂苷3、5和6以及三种已知的皂苷1、2和4。新化合物的结构是建立在HRMS，一维和二维核磁共振光谱数据的基础上完整的皂苷，和GC-MS分析的糖。化合物1、2和5、6对哺乳动物细胞株具有细胞毒性。
Bioassay-guided fractionation of the MeOH extract of Acacia tenuifolia using the engineered yeast strains 1138, 1140, 1353, and Sc7 as the bioassay tool resulted in the isolation of the three new saponins 3, 5, and 6 and the three known saponins 1, 2, and 4. The structures of the new compounds were established on the basis of HRMS, 1D and 2D NMR spectral data on the intact saponins, and GC-MS analyses of the sugars. Compounds 1,2 and 5,6 showed cytotoxicity against mammalian cell lines.