Frequent ice cream consumption is associated with reduced striatal response to receipt of an ice cream-based milkshake
Frequent ice cream consumption is associated with reduced striatal response to receipt of an ice cream-based milkshake
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DOI：
10.3945/ajcn.111.027003
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发表时间：
2012-04-01
影响因子：
7.1
通讯作者：
Stice, Eric
中科院分区：
文献类型：
--
作者：
Burger, Kyle S.;Stice, Eric
背景：体重增加导致奖励区对能量密集型食物的反应性降低，与等热量、低能量密度饮食相比，能量密集型饮食的消耗会导致多巴胺受体减少。此外，重复摄入该食物后，向可口食物接收发出的阶段性多巴胺信号会减少，这总体表明频繁摄入能量密集的食物可能会减少纹状体对该食物的反应。 目的：我们测试了这样的假设：频繁食用冰淇淋与奖励相关大脑区域（例如纹状体）响应于收到冰淇淋奶昔的激活减少有关，并检查了脂肪组织的影响和这种关系的特异性。设计：健康体重青少年（n = 151）在收到奶昔和收到无味溶液期间接受了功能磁共振成像。评估了身体脂肪百分比、报告的食物摄入量以及对食物的渴望和喜好。结果：奶昔的摄入强烈激活了纹状体区域，但频繁食用冰淇淋与这些与奖励相关的大脑区域对奶昔的反应降低有关。身体脂肪百分比、总能量摄入量、来自脂肪和糖的能量百分比以及其他能量密集食物的摄入量与对奶昔的神经反应无关。结论：我们的研究结果提供了新的证据，表明频繁食用冰淇淋，与身体脂肪无关，与人类奖励区反应性的降低有关，与吸毒成瘾中观察到的耐受性相似。数据还表明，摄入特定的能量密集型食物会导致奖励区域对该食物的反应性减弱，这表明饮食和奖励学习的感官方面可能会驱动特异性。 《美国临床杂志》2012 年 3 月；95:810-7。
Background: Weight gain leads to reduced reward-region responsivity to energy-dense food receipt, and consumption of an energy-dense diet compared with an isocaloric, low-energy-density diet leads to reduced dopamine receptors. Furthermore, phasic dopamine signaling to palatable food receipt decreases after repeated intake of that food, which collectively suggests that frequent intake of an energy-dense food may reduce striatal response to receipt of that food.Objective: We tested the hypothesis that frequent ice cream consumption would be associated with reduced activation in reward-related brain regions (eg, striatum) in response to receipt of an ice cream based milkshake and examined the influence of adipose tissue and the specificity of this relation.Design: Healthy-weight adolescents (n = 151) underwent fMRI during receipt of a milkshake and during receipt of a tasteless solution. Percentage body fat, reported food intake, and food craving and liking were assessed.Results: Milkshake receipt robustly activated the striatal regions, yet frequent ice cream consumption was associated with a reduced response to milkshake receipt in these reward-related brain regions. Percentage body fat, total energy intake, percentage of energy from fat and sugar, and intake of other energy-dense foods were not related to the neural response to milkshake receipt.Conclusions: Our results provide novel evidence that frequent consumption of ice cream, independent of body fat, is related to a reduction in reward-region responsivity in humans, paralleling the tolerance observed in drug addiction. Data also imply that intake of a particular energy-dense food results in attenuated reward-region responsivity specifically to that food, which suggests that sensory aspects of eating and reward learning may drive the specificity. Am J Clin Mar 2012;95:810-7.