Misclassification of maternal smoking status and its effects on an epidemiologic study of pregnancy outcomes
Misclassification of maternal smoking status and its effects on an epidemiologic study of pregnancy outcomes
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DOI：
10.1080/14622200701491255
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发表时间：
2007-01-01
影响因子：
4.7
通讯作者：
Levine, Richard J.
中科院分区：
文献类型：
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作者：
England, Lucinda J.;Grauman, Alyssa;Levine, Richard J.
依赖孕妇自我报告的吸烟状况可能导致暴露分类错误。我们使用了钙预防先兆子痫试验的数据，这是一项1992年至1995年对未经产妇女进行的随机研究，旨在描述在研究登记时报告已戒烟的妇女的烟草暴露错误分类。尿可替宁浓度被用来验证戒烟状态，与暴露错误分类相关的因素以及错误分类对吸烟和妊娠结局之间关联的影响使用logistic回归进行评估。在4，289名女性中，508人自我报告吸烟，771人自我报告戒烟。在737名自我报告的戒烟者中，有21.6%的人有主动吸烟的证据，并被重新归类为吸烟者。报告在怀孕期间戒烟的妇女比报告在怀孕前戒烟的妇女更容易被重新分类（p
Reliance on self-reported smoking status among pregnant women can result in exposure misclassification. We used data from the Calcium for Preeclampsia Prevention trial, a randomized study of nulliparous women conducted from 1992 to 1995, to characterize tobacco exposure misclassification among women who reported at study enrollment that they had quit smoking. Urinary cotinine concentration was used to validate quit status, and factors associated with exposure misclassification and the effects of misclassification on associations between smoking and pregnancy outcomes were evaluated using logistic regression. Of 4,289 women enrolled, 508 were self-reported smokers and 771 were self-reported quitters. Of 737 self-reported quitters with a valid cotinine measurement, 21.6% had evidence of active smoking and were reclassified as smokers. Women who reported having quit smoking during pregnancy were more likely to be reclassified than women who reported quitting before pregnancy (p