Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy
Controllable photodynamic performance via an acidic microenvironment based on two-dimensional metal-organic frameworks for photodynamic therapy
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基于二维金属有机框架的酸性微环境的光动力治疗可控光动力性能
DOI：
10.1007/s12274-020-3093-1
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发表时间：
2020-11-15
期刊：
影响因子：
9.9
通讯作者：
Jiang, Guihua
中科院分区：
文献类型：
--
作者：
Hang, Lifeng;Zhang, Tao;Jiang, Guihua
光动力学疗法（PDT）是一种广泛应用于癌症治疗的技术，但传统光敏剂仍面临一些缺点，如疏水性、药代动力学不足、细胞/组织特异性低以及在治疗过程中光动力学性能不可控。在此，我们提出了一个可控的光动力学性能的基础上的二维金属-有机框架（2D Zn-TCPP MOF），显示了一个星期的PDT效应在中性环境下暴露于660 nm的激光，由于Q带的TCPP的简并。然而，2D Zn-TCPP MOF在酸性环境中在660 nm激光照射下显示出显著增强的PDT效应，这是由于从分解的MOF结构释放的TCPP。从体外结果来看，2D Zn-TCPP MOF从中性到酸性环境都表现出可控的光动力学性能。由于酸性肿瘤微环境，2D Zn-TCPP MOF在660 nm激光照射下呈现出最强的体内抗肿瘤作用。这项工作为开发下一代光敏剂提供了一个有前途的策略。
Photodynamic therapy (PDT) is a widely-used technology for cancer therapy, but conventional photosensitizers still face some drawbacks, such as hydrophobicity, inadequate pharmacokinetics, low cell/tissue specificity, and uncontrollable photodynamic performance during the therapeutic process. Herein, we present a controllable photodynamic performance based on two-dimensional metal-organic frameworks (2D Zn-TCPP MOF) that displayed a week PDT effect under a neutral environment upon exposure to a 660 nm laser due to the degeneracy of Q bands of TCPP. However, the 2D Zn-TCPP MOF showed a significantly enhanced PDT effect in an acidic environment under irradiation with a 660 nm laser due to the released TCPP from decomposed MOF structure. From the in vitro outcomes, the 2D Zn-TCPP MOF showed controllable photodynamic performance from neutral to acidic environments. Due to the acidic tumor microenvironment, the 2D Zn-TCPP MOF presented the strongest antitumor effect in vivo under irradiation with a 660 nm laser. This work offers a promising strategy to develop a next-generation photosensitizer.