The 2007 WHO classification of tumors of the central nervous system - what has changed?
The 2007 WHO classification of tumors of the central nervous system - what has changed?
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DOI：
10.1097/wco.0b013e328312c3a7
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发表时间：
2008-12-01
影响因子：
4.8
通讯作者：
Duyckaerts, Charles
中科院分区：
文献类型：
--
作者：
Rousseau, Audrey;Mokhtari, Karima;Duyckaerts, Charles
综述的目的随着对癌症生物学的理解不断进步，每5年左右就需要对任何现有的肿瘤分类进行修订。除其他外，基因组分析技术正在迅速发展，必须整合新的信息以更新任何此类分类。第四版的WHO分类中枢神经系统的肿瘤是在2007年出版的，旨在建立一个命名，使用和接受世界各地，并在纳入最新进展的领域。最近findingsThe 2007 WHO分类集中在中枢神经系统的肿瘤。自2000年上一次分类以来成立的几个新确认的实体已被列入。丰富的基因组数据已被添加，不同的遗传变异代表了定义肿瘤子集的标准，例如少突胶质瘤中的1 p/19 q共缺失。然而，形态学仍然是世界卫生组织分类的金标准。总结其他新的临床相关且仔细定义的实体预计将在不久的将来加入不断增长的脑肿瘤名单。细胞遗传学和分子遗传学的新工具正在迅速改变中枢神经系统肿瘤领域。在临床常规实践中整合遗传数据至关重要。一个真正的组织发生学命名法可能是WHO中枢神经系统肿瘤分类的下一步。
Purpose of reviewAs progress is being made in understanding the biology of cancer, revision to any current tumor classification is needed every 5 years or so. Technology of genomic analysis, among others, is evolving rapidly and new information has to be integrated to update any such classification. The fourth edition of the WHO classification of tumors of the central nervous system was published in 2007 and aims at establishing a nomenclature that is used and accepted worldwide, and at incorporating the latest advances in the field.Recent findingsThe 2007 WHO classification is focused on neoplasms of the central nervous system. Several newly recognized entities, which have become established since the previous, 2000 classification have been included. A wealth of genomic data has been added and distinct genetic alterations represent criteria to define tumor subsets, such 1p/19q codeletion in oligodendrogliomas. Yet, morphology is still the gold standard of the WHO classification.SummaryOther novel clinically relevant and carefully defined entities are expected to join the growing list of brain tumors in the near future. New tools in cytogenetics and molecular genetics are rapidly changing the field of central nervous system neoplasms. Integrating genetic data in clinical routine practice is essential. A true histogenetic nomenclature may be the next step for the WHO classification of central nervous system neoplasms.