Environmental stress and ovarian function.
Environmental stress and ovarian function.
复制标题
环境压力与卵巢功能。
DOI：
10.1095/biolreprod34.1.29
复制
发表时间：
1986
影响因子：
3.6
通讯作者：
David T. Armstrong
中科院分区：
文献类型：
--
作者：
David T. Armstrong
女性生殖系统暴露于各种各样的环境压力。这些包括许多有毒化学物质，它们要么是以治疗和娱乐药物的形式被有意地消耗，要么是在我们吃的食物中无意地残留下来，或者是我们呼吸的空气中的污染物。这些压力和有害物质通过许多部位的作用和不同的机制影响卵巢功能。采取行动的地点包括：下丘脑-垂体系统，导致促性腺激素分泌的正常模式中断;卵巢，导致卵母细胞的直接破坏（卵毒性）或遗传损伤（致突变性）;以及其他器官，间接导致卵巢功能改变，例如，通过改变下丘脑-垂体-卵巢系统反馈控制平衡的代谢改变。卵巢对不同种类药剂的敏感性取决于暴露发生时的发育阶段。当“压力”源被移除时，后果可能是暂时的和可逆的，或者如果暴露发生在卵巢或下丘脑分化的“关键阶段”，则后果可能是永久的。
The female reproductive system is exposed to a great variety of environmental stresses. These include many noxious chemicals consumed either intentionally in the form of therapeutic and recreational drugs, or unwittingly as residues in the food we eat or pollutants in the air we breathe. These stresses and noxious agents influence ovarian function through actions at a number of sites and by diverse mechanisms. Sites of action include: the hypothalamo-hypophyseal system, resulting in disruption of the normal pattern of gonadotropin secretion; the ovary, resulting in direct destruction of the oocyte (ovotoxicity) or genetic damage (mutagenicity); and other organs, leading indirectly to altered ovarian function, e.g., through metabolic alterations that change the balance of feedback control of the hypothalamo-pituitary-ovarian system. Susceptibility of the ovaries to the different classes of agents depends on the stage of development at which exposure occurs. Consequences may be temporary and reversible when the source of the "stress" is removed, or permanent if exposure occurs at a "critical stage" in ovarian or hypothalamic differentiation.
母亲压力对男性后代性行为的影响。
DOI：
10.1159/000406889
发表时间：
1983
期刊：
Monographs in neural sciences
影响因子：
--
作者：
Ward,IL
通讯作者：
Ward,IL
母体压力会降低雄性和雌性大鼠胎儿大脑中类固醇芳香酶的活性。
影响因子：
4.1
作者：
Weisz,J;Brown,BL;Ward,IL
通讯作者：
Ward,IL