Spatial and Temporal Organization of the Individual Human Cerebellum
Spatial and Temporal Organization of the Individual Human Cerebellum
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DOI：
10.1016/j.neuron.2018.10.010
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发表时间：
2018-11-21
期刊：
影响因子：
16.2
通讯作者：
Dosenbach, Nico U. F.
中科院分区：
文献类型：
--
作者：
Marek, Scott;Siegel, Joshua S.;Dosenbach, Nico U. F.
小脑包含人脑中的大多数神经元，并且因其均匀的细胞结构、无有氧糖酵解以及在适应性可塑性中的作用而独特。尽管小脑和大脑皮层之间存在解剖学和生理学差异，但组平均功能连接研究已经确定了与两种结构中特定功能相关的网络。最近，对个体的精确功能映射显示，大脑皮层中的功能网络表现出可测量的个体特异性。使用高度采样的Midnight Scan Club（MSC）数据集，我们发现小脑包含可靠的，个体特异性的网络组织，比大脑皮层更易变。被认为支持适应性控制的额顶叶网络是唯一一个在小脑中过度表达的网络，是大脑皮层的2.3倍。在时间上，所有小脑静息状态信号都滞后于大脑皮层（125-380 ms），支持小脑参与所有皮层过程的自适应控制的域一般功能的假设。
The cerebellum contains the majority of neurons in the human brain and is unique for its uniform cytoarchitecture, absence of aerobic glycolysis, and role in adaptive plasticity. Despite anatomical and physiological differences between the cerebellum and cerebral cortex, group-average functional connectivity studies have identified networks related to specific functions in both structures. Recently, precision functional mapping of individuals revealed that functional networks in the cerebral cortex exhibit measurable individual specificity. Using the highly sampled Midnight Scan Club (MSC) dataset, we found the cerebellum contains reliable, individual-specific network organization that is significantly more variable than the cerebral cortex. The frontoparietal network, thought to support adaptive control, was the only network over-represented in the cerebellum compared to the cerebral cortex (2.3-fold). Temporally, all cerebellar resting state signals lagged behind the cerebral cortex (125-380 ms), supporting the hypothesis that the cerebellum engages in a domain-general function in the adaptive control of all cortical processes.