Immune evasion and provocation by Mycobacterium tuberculosis.
Immune evasion and provocation by Mycobacterium tuberculosis.
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DOI：
10.1038/s41579-022-00763-4
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发表时间：
2022-12
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--
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中科院分区：
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结核分枝杆菌是结核病的病原体，几千年来一直感染人类。结核分枝杆菌很好地适应了感染，面对宿主的免疫反应持续存在，并传播给未感染的人。它完成这一感染周期的能力取决于它能否避开和利用宿主的免疫反应。结核分枝杆菌感染的结果往往是一种平衡状态，其特征是免疫控制和细菌持续存在。最近的数据突出了对结核分枝杆菌感染作出反应的不同细胞群体，以及结核分枝杆菌在感染过程中细胞和细胞内生态位的动态变化。结核分枝杆菌拥有大量影响巨噬细胞功能和炎症反应的蛋白质和脂质效应物；然而，我们对特定细菌毒力因子在不同细胞库和不同感染阶段所起作用的了解有限。在这篇综述中，我们讨论了结核分枝杆菌在感染周期中的免疫逃避和激发，并描述了更详细的分子理解对于开发新的宿主导向疗法、疾病生物标记物和有效疫苗是至关重要的。在这篇综述中，Chandra、Grigsby和菲利普斯讨论了结核分枝杆菌如何在其生命周期的不同阶段利用宿主炎症反应的同时逃避免疫介导的清除。他们将重点放在最近的研究上，强调知识中的差距，并考虑我们目前的理解将如何为新的疗法、疫苗和诊断提供信息。
Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host immune response and be transmitted to uninfected individuals. Its ability to complete this infection cycle depends on it both evading and taking advantage of host immune responses. The outcome of M. tuberculosis infection is often a state of equilibrium characterized by immunological control and bacterial persistence. Recent data have highlighted the diverse cell populations that respond to M. tuberculosis infection and the dynamic changes in the cellular and intracellular niches of M. tuberculosis during the course of infection. M. tuberculosis possesses an arsenal of protein and lipid effectors that influence macrophage functions and inflammatory responses; however, our understanding of the role that specific bacterial virulence factors play in the context of diverse cellular reservoirs and distinct infection stages is limited. In this Review, we discuss immune evasion and provocation by M. tuberculosis during its infection cycle and describe how a more detailed molecular understanding is crucial to enable the development of novel host-directed therapies, disease biomarkers and effective vaccines. In this Review, Chandra, Grigsby and Philips discuss how Mycobacterium tuberculosis evades immune-mediated clearance while capitalizing on the host inflammatory response at different phases of its life cycle. They focus on recent studies, highlight gaps in knowledge and consider how our current understanding will inform new therapies, vaccines and diagnostics.
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DOI：
10.4049/jimmunol.1601199
发表时间：
2017-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Athman JJ;Sande OJ;Groft SG;Reba SM;Nagy N;Wearsch PA;Richardson ET;Rojas R;Boom WH;Shukla S;Harding CV
通讯作者：
Harding CV
影响因子：
6.4
作者：
Bell SL;Lopez KL;Cox JS;Patrick KL;Watson RO
通讯作者：
Watson RO
影响因子：
7.3
作者：
Carvalho ACC;Amorim G;Melo MGM;Silveira AKA;Vargas PHL;Moreira ASR;Rocha MS;Souza AB;Arriaga MB;Araújo-Pereira M;Figueiredo MC;Durovni B;Lapa-E-Silva JR;Cavalcante S;Rolla VC;Sterling TR;Cordeiro-Santos M;Andrade BB;Silva EC;Kritski AL;RePORT Brazil consortium
通讯作者：
RePORT Brazil consortium
影响因子：
64.8
作者：
通讯作者：
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影响因子：
6.7
作者：
Bold TD;Banaei N;Wolf AJ;Ernst JD
通讯作者：
Ernst JD