Relationship between bisphenol A exposure and attention-deficit/hyperactivity disorder: A case-control study for primary school children in Guangzhou, China
Relationship between bisphenol A exposure and attention-deficit/hyperactivity disorder: A case-control study for primary school children in Guangzhou, China
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双酚A暴露与注意力缺陷/多动障碍的关系：针对中国广州小学生的病例对照研究
DOI：
10.1016/j.envpol.2017.12.056
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发表时间：
2018-04-01
影响因子：
8.9
通讯作者：
Pang, Qihua
中科院分区：
文献类型：
--
作者：
Li, Yanru;Zhang, Haibin;Pang, Qihua
双酚A(BPA)是一种干扰内分泌的化学物质。研究表明，暴露在双酚A中与青少年发育期间的注意力缺陷/多动障碍(ADHD)有关。然而，直接的临床证据是有限的。为探讨环境双酚A暴露与儿童行为改变的关系，对广州市6~12岁儿童中国进行了病例对照研究。以广州地区215名ADHD儿童和253名健康儿童为病例组，253名为对照组。用高效液相色谱/串联光谱仪测定尿BPA和8-羟基-2‘-脱氧鸟苷(8-OHdG，DNA氧化损伤的生物标志物)浓度。结果表明，病例组尿SPA浓度显著高于对照组(3.44vs1.70mgCrt；4.63vs1.71mgCrt)。P<；.001)。ADHD的OR值随着儿童尿BPA四分位数的增加而递增(第一四分位数：参考类别；第二四分位数调整后OR：1.79，95%CI：0.95~3.37；第三四分位数调整OR：7.44，95%CI：3.91~14.1；第四四分位数调整OR：9.41，95%CI：4.91~18.1)。当BPA水平按性别分层时，男孩和女孩患ADHD的几率随着尿中BPA浓度的增加而显著增加(调整OR：4.58，95%CI：2.84~7.37；调整OR：2.83，95%CI：1.17~6.84)。ADHD患儿尿8-OHdG浓度明显高于对照组。此外，线性回归分析结果表明，双酚A暴露与8-OHdG水平之间存在显著的相关性(R=0.257，p<；.001)。我们的发现提供了直接证据，表明儿童时期接触双酚A可能与儿童的ADHD和8-OHdG浓度有关。此外，接触双酚A会增加男孩比女孩更高的ADHD发生率。(C)2017爱思唯尔有限公司。保留所有权利。
Bisphenol A (BPA) is an endocrine-disrupting chemical. Studies have shown that the exposure to BPA is associated with attention-deficit/hyperactivity disorder (ADHD) during adolescent development. However the direct clinical evidence is limited. To investigate the possible association between environmental BPA exposure and the altered behavior of children, a case-control study was conducted with children aged 6-12 years in Guangzhou, China. Two hundred fifteen children diagnosed with ADHD and 253 healthy children from Guangzhou were recruited as the case and control groups, respectively. Urinary BPA and 8-hydroxy-2'-deoxyguanosine (8-OHdG, a biomarker of oxidative DNA damage) concentrations were determined by high-performance liquid chromatography/tandem spectrometry. The results showed that concentrations of urinary SPA for the case group were significantly higher than those for the control group (3.44 vs 1.70 mu g/L; 4.63 vs 1.71 mu g/g Crt. p < .001). A stepwise increase in the odds ratios for ADHD was observed with the increasing quartiles of children's urinary BPA (first quartile: reference category; second quartile adjusted OR: 1.79, 95% CI: 0.95-3.37; third quartile adjusted OR: 7.44, 95% CI: 3.91-14.1; fourth quartile adjusted OR: 9.41, 95% CI: 4.91-18.1). When the BPA levels were stratified by gender, the odds of ADHD among boys and girls increased significantly with urinary BPA concentrations (adjusted OR: 4.58, 95% CI: 2.84-7.37; adjusted OR: 2.83, 95% CI: 1.17-6.84). Urinary 8-OHdG concentrations in the ADHD children were significantly higher than those in the control group. Furthermore, the linear regression analysis results indicated that a significant relationship existed between BPA exposure and 8-OHdG levels (R = 0.257, p < .001). Our findings provide direct evidence that childhood BPA exposure may be related to ADHD and 8-OHdG concentrations for children. Moreover, BPA exposure could increase the higher occurrence of ADHD for boy than for girls. (C) 2017 Elsevier Ltd. All rights reserved.