Severe systemic lupus erythematosus in emergency department: a retrospective single-center study from China
Severe systemic lupus erythematosus in emergency department: a retrospective single-center study from China
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急诊科重症系统性红斑狼疮：来自中国的回顾性单中心研究
DOI：
10.1007/s10067-011-1826-y
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发表时间：
2011-08
影响因子：
3.4
通讯作者：
Lu, Xiaoye
中科院分区：
文献类型：
--
作者：
Zhu, Chang-qing;Ye, Shuang;Chen, Guang-liang;Chen, Yi;Yang, Cheng-de;Lu, Xiaoye
本研究描述了在上海仁济医院急诊科就诊的重症系统性红斑狼疮（SLE）患者的特征，目的是确定病因、结局和预后因素。本回顾性研究纳入了2007年1月至2010年8月期间到急诊科就诊，随后住院或在急诊科死亡的SLE患者。在131例SLE急诊事件中，总死亡率为16.8%。年龄较大（≥45岁）、病程较长、存在肺动脉高压、肾功能不全和侵袭性感染是危险因素。与存活者相比，死亡者具有较高的器官损害指数（SLICC，3.86 ± 2.14vs.0.93 ± 1.14，p < 0.001）和较低的疾病活动性（SLEDAI，11.5 ± 7.7vs.16.5 ± 9.0，p = 0.015）。近期发病（病程≤3个月）的SLE占急诊患者的32.1%，且具有明显的年轻化特征，神经精神和血液学表现的频率较高。在这些患者中可以观察到95.2%生存率的良好短期结局。年龄较大、病程较长和重要器官的累积损害决定了重症SLE在急诊科的短期预后。认识到疾病模式和客观的预后参数可能有助于医生提供更好的照顾，基于风险拟合的方法，为SLE患者在紧急情况下。
This study describes the characteristics of severe systemic lupus erythematosus (SLE) patients who visited the emergency department of the Shanghai Renji Hospital, and the aim is to identify the causes, the outcome, and the prognostic factors. SLE patients who visited the emergency department between January 2007 and August 2010, and who were subsequently hospitalized or who died in emergency department, were included in this retrospective study. Of the total 131 SLE emergency events, overall mortality was 16.8%. Older age (≥45 years), longer duration of disease, presence of pulmonary hypertension, renal insufficiency, and invasive infections are risk factors. Higher organ damage index (SLICC, 3.86 ± 2.14 vs. 0.93 ± 1.14,p< 0.001) but relatively lower disease activity (SLEDAI, 11.5 ± 7.7 vs. 16.5 ± 9.0,p= 0.015) were the characteristics of the deceased when compared with the survivors. Recent-onset (duration of disease ≤3 months) SLE accounts for 32.1% of the patients in emergency, and this group showed a distinctive pattern of younger age with higher frequencies of neuropsychiatric and hematologic manifestations. A good short-term outcome with a 95.2% survival rate can be observed in such patients. Older age, longer disease duration and cumulative damage of vital organs determine the short-term outcome of severe SLE in the emergency department. Recognizing disease patterns and objective prognostic parameters may help physicians to provide better care, based on a risk-fitted approach, for the SLE patients in emergencies.
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影响因子：
--
作者：
Nada Alaaeddine;J. Battista;J. Pelletier;K. Kiansa;Cloutier Jm;J. Martel-Pelletier
通讯作者：
Nada Alaaeddine;J. Battista;J. Pelletier;K. Kiansa;Cloutier Jm;J. Martel-Pelletier
影响因子：
3
作者：
M. Petri;S. Perez-Gutthann;J. Longenecker;M. Hochberg
通讯作者：
M. Petri;S. Perez-Gutthann;J. Longenecker;M. Hochberg
DOI：
--
发表时间：
2006-08
期刊：
The Journal of rheumatology
影响因子：
--
作者：
M. Ward;Jennifer Odutola
通讯作者：
M. Ward;Jennifer Odutola
影响因子：
27.4
作者：
Lee, CK;Ahn, MS;Moon, HB
通讯作者：
Moon, HB
DOI：
10.1002/art.23346
发表时间：
2008-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Ward, Michael M.
通讯作者：
Ward, Michael M.