Shell-by-shell synthesis of multi-shelled mesoporous silica nanospheres for optical imaging and drug delivery
Shell-by-shell synthesis of multi-shelled mesoporous silica nanospheres for optical imaging and drug delivery
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DOI：
10.1016/j.biomaterials.2010.08.114
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发表时间：
2011-01-01
期刊：
影响因子：
14
通讯作者：
Yeh, Chen-Sheng
中科院分区：
文献类型：
--
作者：
Huang, Chih-Chia;Huang, Wileen;Yeh, Chen-Sheng
自模板合成包括通道内壁保护和最外层表面钝化是成功合成多壳介孔二氧化硅纳米球的关键。采用逐壳法制备双壁和三壁介孔二氧化硅纳米球，其尺寸约为100 nm。多壳介孔二氧化硅可形成类似于110 nm双壳结构和类似于140 nm三壳尺寸的振荡型或中空结构，特别是壳层到壳层的距离可以通过控制自模板化过程的腐蚀周期来调节，而不改变多壳尺寸或多核直径。壳层介孔纳米结构通过在壳层空腔和多孔壳中引入功能物种，为开发多功能载体提供了平台。将荧光团和药物包裹在壳层空间和介孔壳层中表明，通过适当选择pH依赖的分子，多壳二氧化硅微球可以以双重方式用于成像和药物共输送载体。体外评价表明，负载在外周空间的抗癌药物阿霉素(DOX)被成功地携带并释放到细胞质中，而荧光素FITC(主要分布于胞核)。在内周空间)被有效地包裹在球体内双壳和三壳纳米球在体外和体内始终提供具有可见跟踪能力的成像探针由爱思唯尔有限公司出版皇冠(C)2010版权所有
Self-templated synthesis involving interior channel wall protection as well as outermost surface passivation was crucial to successful synthesis of multi-shelled mesoporous silica nanospheres The shell-by-shell fabrication of double- and triple-walled mesoporous silica nanospheres downsized to similar to 100 nm The multi-shelled mesoporous silica can be built as rattle-type or hollow structures with similar to 110 nm of double-shelled and similar to 140 nm of triple-shelled sizes Notably the shell-to-shell distance can be tuned by controlling the etching period from the self-templation processes without changing the multi-shelled size or interior core diameter The multi-shelled mesoporous nanostructures provide a platform for the development of a multifunctional vector by the inclusion of functional species into shell-to-shell cavities and porous shells The encapsulation of the fluorophore and drug in shell-to-shell space and mesoporous shells showed that multi-shelled silica spheres can be used in dual-modality for imaging and drug co-delivery vectors through the appropriate selection of pH-dependent molecules The in vitro evaluation in triple-shelled silica indicated that an anti-cancer doxorubicin (DOX) loaded in the outer periphery space was successfully carried and released in the cytoplasm then entered nuclei while fluorescein FITC (primarily distributed in Inner periphery space) was effectively encapsulated inside the spheres The double- and triple-shelled nanospheres consistently provided imaging probes with visible tracking capability in vitro and in vivo Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved