Theranostic magnetoliposomes coated by carboxymethyl dextran with controlled release by low-frequency alternating magnetic field
Theranostic magnetoliposomes coated by carboxymethyl dextran with controlled release by low-frequency alternating magnetic field
复制标题
低频交变磁场控释羧甲基葡聚糖包被的治疗诊断磁脂质体
DOI：
10.1016/j.carbpol.2014.10.076
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发表时间：
2015-03-15
影响因子：
11.2
通讯作者：
Wang, Jianxiu
中科院分区：
文献类型：
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作者：
Guo, Hongyan;Chen, Wansong;Wang, Jianxiu
本研究的目的是构建羧甲基右旋糖酐（CMD）包被磁脂质体（MLs），这是另一种替代聚乙二醇化MLs的隐形MLs，用于治疗应用。特别地，研究了在低频交变磁场（LF-AMF）作用下，cd - mls的按需释放。我们发现制备的MLs对阿霉素（DOX）具有良好的稳定性和高的载药能力。对人神经母细胞瘤SH-SY5Y细胞的细胞毒性试验表明，由于DOX的持续释放，负载DOX的CMD-MLs的毒性低于游离DOX。然而，在不产生热疗的情况下，低频交变磁场增强了dox负载的CMD-MLs的释放。在体外MRI测量中，MLs也作为一种有效的t -2加权造影剂。上述结果提供了有关dox负载的CMD-MLs对某些癌症（如脑癌）的体内诊断/治疗功效的有用信息。(C) 2014 Elsevier Ltd.版权所有。
The aim of this work was to construct carboxymethyl dextran (CMD)-coated magnetoliposomes (MLs), another stealth MLs alternative to PEGylated MLs, for theranostic application. Particularly, the on-demand release of CMD-MLs under low-frequency alternating magnetic field (LF-AMF) was studied. We found that as-prepared MLs exhibited good stability and high drug loading ability for doxorubicin (DOX). Cytotoxicity assay against human neuroblastoma SH-SY5Y cells showed that the DOX-loaded CMD-MLs were less toxic than free DOX due to the sustained release of DOX. However, the release of DOX-loaded CMD-MLs was enhanced by low-frequency alternating magnetic field without hyperthermia generation. The MLs also acted as an efficient T-2-weighted contrast agent during in vitro MRI measurements. The above results provide useful information on in vivo diagnostic/therapeutic efficacy of DOX-loaded CMD-MLs for some cancers, such as brain cancers. (C) 2014 Elsevier Ltd. All rights reserved.