Pseudocontinuous arterial spin labeling perfusion magnetic resonance imaging-A normative study of reproducibility in the human brain
Pseudocontinuous arterial spin labeling perfusion magnetic resonance imaging-A normative study of reproducibility in the human brain
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DOI：
10.1016/j.neuroimage.2011.02.080
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Lien, Shu-Hua
中科院分区：
文献类型：
--
作者：
Wu, Wen-Chau;Jiang, Shu-Fen;Lien, Shu-Hua
伪连续动脉自旋标记（PCASL）是一种新提出的灌注磁共振成像（MRI）技术，与传统的ASL方法相比，它有可能在标记效率和信噪比之间提供更好的平衡。在达到充分的可重复性之前，这种优势是无法利用的。在这项研究中，我们通过考虑线圈灵敏度（CS）和标记效率（alpha）的校正，研究了PCASL在12名健康志愿者身上的可重复性。每个受试者都经历了两次相同的疗程，时间间隔为两周。为了比较，脉冲ASL （PASL）成像也采用流动敏感交替反演恢复方法进行。采用12通道相控阵对3T全身系统进行MR成像。对灰质的血流进行量化，并对整体以及颈内动脉和大脑后动脉的血流区域进行评估。实验结果表明，CS分别占PCASL和PASL会话间变异的35%和60%。单独进行CS校正后，PCASL的方差系数（CV）仍然大于PASL （p = 0.02）。CS校正的PASL CV为12%，CS和alpha联合校正的PCASL CV为11%。我们得出结论，当使用相控阵接收器时，ASL成像需要CS校正，并且在CS校正后，PCASL需要alpha校正以提供与PASL相当的再现性。(C) 2011爱思唯尔公司版权所有。
Pseudocontinuous arterial spin labeling (PCASL), a newly proposed perfusion magnetic resonance imaging (MRI) technique, has the potential of providing a better balance between labeling efficiency and signal-to-noise ratio than conventional ASL methods. The advantage will not be exploitable until adequate reproducibility can be achieved. In this study, we investigated the reproducibility of PCASL on twelve healthy volunteers by taking into account the inclusion of correction for coil sensitivity (CS) and labeling efficiency (alpha). Each subject underwent two identical sessions scheduled two weeks apart. For comparison, pulsed ASL (PASL) imaging was also conducted using the flow-sensitive alternating inversion recovery method. MR imaging was performed on a 3T whole body system using a 12-channel phased array for reception. Blood flow was quantified for gray matter and assessed globally as well as in the flow territories of the internal carotid arteries and posterior cerebral arteries. Experimental results showed that CS accounted for 35% and 60% of inter-session variability in PCASL and PASL, respectively. With CS correction alone, coefficient of variance (CV) remained larger with PCASL than PASL (p = 0.02). CV was 12% with CS-corrected PASL and 11% with PCASL when CS and alpha were corrected for in conjunction. We concluded that CS correction is necessary for ASL imaging when using phased array receiver and that after CS correction, PCASL requires alpha correction to provide reproducibility comparable to PASL. (C) 2011 Elsevier Inc. All rights reserved.