Sepsis and immune response.
Sepsis and immune response.
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DOI：
10.5847/wjem.j.issn.1920-8642.2011.02.002
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发表时间：
2011
影响因子：
2.1
通讯作者：
Xingyuan Chen;Y. Yin;Jingxiao Zhang
中科院分区：
文献类型：
--
作者：
Xingyuan Chen;Y. Yin;Jingxiao Zhang
背景脓毒症和继发性多器官功能衰竭是危重病患者的主要死亡原因，但其发病机制尚不清楚，尤其是免疫系统功能障碍。本文就脓毒症中免疫系统的反应和调节以及多种炎症介质的作用作一综述。资料来源：通过检索MEDLINE和PubMed的文章，检索词为“败血症”、“免疫反应”和“炎症介质”，限定文章的语言种类为2010年10月。通过对关键文章的参考文献进行手动搜索，确定了其他论文。结果该综述涉及：1)免疫反应；2)免疫调节；3)炎症介质；4)高迁移率族蛋白1蛋白；5)补体系统；6)自主神经系统。目前还没有针对炎症反应的脓毒症的治疗方法；脓毒症的死亡率并没有显著降低。结论脓毒症是复杂的、动态的，具有一组不同的证候。由于不同的脓毒症患者有不同的病因、易感性和反应，因此应该单独开出治疗药物。
BACKGROUND Sepsis and secondary multiple organ failure in critically ill patients are the major cause of death, but the pathogenesis of sepsis is not clear, especially the dysfunction of the immune system. In this paper, we review the response and regulation of the immune system and the functions of a variety of inflammatory mediators in sepsis. DATA SOURCES Studies were identified by searching MEDLINE and PubMed for articles using the keywords "sepsis", "immune response", and "inflammatory mediator" up to October 2010. Additional papers were identified by a manual search of the references from the key articles. RESULTS THIS SYSTEMATIC REVIEW WAS CONDUCTED OF: 1) the immune response; 2) immune regulation; 3) inflammatory mediators; 4) high-mobility group box 1 protein; 5) the complement system; and 6) the autonomic nervous system. There are no therapeutic approaches available for sepsis that target inflammatory response; the mortality of sepsis has not been significantly reduced. CONCLUSIONS Sepsis is complex and dynamic, and it has a group of heterogeneous syndromes. Since different patients with sepsis have different etiology, susceptibility, and responses, treatment should be prescribed individually.