Incidence and mortality of multiple myeloma in China, 2006-2016: an analysis of the Global Burden of Disease Study 2016
Incidence and mortality of multiple myeloma in China, 2006-2016: an analysis of the Global Burden of Disease Study 2016
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DOI：
10.1186/s13045-019-0807-5
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发表时间：
2019-12-10
影响因子：
28.5
通讯作者：
Wang, Lijun
中科院分区：
文献类型：
--
作者：
Liu, Jiangmei;Liu, Weiping;Wang, Lijun
背景资料：方法：按照GBD 2016的总体分析策略，分析中国多发性骨髓瘤（MM）的发病率和死亡率的年龄、性别和省份特征。结果：2016年我国多发性骨髓瘤新发病例16,500例，死亡10,300例，死亡率为10,300%，死亡率为100%。2016年，每10万人口的年龄标准化发病率（ASIR）和死亡率（ASMR）分别为1.03（95% UI，0.88-1.17）和0.67（95% UI，0.59-0.77）。在所有年龄组中，男性的发病率和死亡率均高于女性。观察到发病率和死亡率随年龄增长呈上升趋势。发达省份的发病率和死亡率较高。2006 - 2016年我国MM发病率显著上升，2006 - 2014年死亡率呈上升趋势，2014 - 2016年保持稳定。结论：我国MM的疾病负担呈现异质性，需要从国家和省两级制定针对性的疾病预防控制策略。
Background: The accurate information about burden of multiple myeloma (MM) at national and provincial level remains unknown in China.Methods: Following the general analytical strategy used in GBD 2016, the age-, sex-, and province-specific incidence and mortality in China were analyzed. Trends in the incidence and mortality from 2006 to 2016 were evaluated.Results: It was estimated that there were 16,500 new cases and 10,300 deaths of multiple myeloma in China in 2016. The age-standardized incidence rates (ASIR) and mortality rates (ASMR) per 100,000 population were 1.03 (95% UI, 0.88-1.17) and 0.67 (95% UI, 0.59-0.77) in 2016. Males had higher incidence and mortality rates than females in all age groups. An upward trend with age in incidence and mortality was observed. Higher incidence and mortality rates clustered in the developed provinces. The incidence of MM in China increased significantly from 2006 to 2016, while the mortality increased from 2006 to 2014, and remained stable from 2014 to 2016.Conclusion: The burden of MM showed a heterogeneous pattern in China, which highlighted the need of tailored disease prevention and control strategies in both national and provincial levels.