Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women
Fidelity of muscle fibre reinnervation modulates ageing muscle impact in elderly women
复制标题
肌纤维神经支配的保真度调节老年女性肌肉老化的影响
DOI：
10.1113/jp278261
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
R. Hepple
中科院分区：
文献类型：
--
作者：
Vita Sonjak;K. Jacob;J. Morais;Marie L. Rivera;S. Spendiff;C. Spake;T. Taivassalo;S. Chevalier;R. Hepple
Susceptibility to age‐related muscle atrophy relates to the degree of muscle denervation and the capacity of successful reinnervation. However, the specific role of denervation as a determinant of the severity of muscle aging between populations with low versus high physical function has not been addressed. We show that prefrail/frail elderly women exhibited marked features of muscle denervation, whereas world class octogenarian female master athletes showed attenuated indices of denervation and greater reinnervation capacity. These findings suggest that the difference in age‐related muscle impact between low‐ and high‐functioning elderly women is the robustness of the response to denervation of myofibers.
