Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk
Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk
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DOI：
10.1152/ajpcell.00113.2011
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发表时间：
2011-10-01
影响因子：
5.5
通讯作者：
Arcangeli, Annarosa
中科院分区：
文献类型：
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作者：
Arcangeli, Annarosa
阿尔坎杰利河癌症中的离子通道和转运蛋白。3.肿瘤细胞内离子通道与微环境的相互作用。美国生理学杂志细胞生理学301：C762-C771，2011年。首次发表于2011年5月11日; doi：10.1152/ajpcell。00113.2011.-传统的观点认为，癌症是增殖细胞的集合，必须重新考虑，癌症必须被视为一个“组织”，由转化细胞和异质性微环境构成，肿瘤细胞在多步骤肿瘤发生过程中构建和重塑。“肿瘤微环境”（TM）由浸入细胞外基质（ECM）蛋白和可溶性因子网络中的间充质细胞、内皮细胞和免疫细胞形成。TM通过长距离、细胞与细胞或细胞与基质信号强烈促进肿瘤进展，其影响肿瘤细胞行为的不同方面。了解癌症组织不同成分之间的关系对于设计和开发新的治疗策略至关重要。离子通道正在成为肿瘤细胞与其TM之间串扰的相关参与者。离子通道在肿瘤细胞上以及TM的不同细胞组分中表达。在所有这些细胞中，离子通道都处于感知细胞外信号并将其传递到细胞内机制的战略地位。通常，这种传递由整合素粘附受体介导，整合素粘附受体可以是离子通道的功能伴侣，因为它们在质膜的背景下与通道蛋白形成分子复合物。同样的相关作用是由离子转运蛋白，这也有助于确定两个方面的癌组织：缺氧和酸性细胞外pH值。总的来说，它是可以想象的前景靶向离子通道的新的治疗策略，旨在更好地控制癌组织的恶性进展。
Arcangeli A. Ion channels and transporters in cancer. 3. Ion channels in the tumor cell-microenvironment cross talk. Am J Physiol Cell Physiol 301: C762-C771, 2011. First published May 11, 2011; doi:10.1152/ajpcell. 00113.2011.-The traditional view of cancer as a collection of proliferating cells must be reconsidered, and cancer must be viewed as a "tissue" constituted by both transformed cells and a heterogeneous microenvironment, that tumor cells construct and remodel during multistep tumorigenesis. The "tumor microenvironment" (TM) is formed by mesenchymal, endothelial, and immune cells immersed in a network of extracellular matrix (ECM) proteins and soluble factors. The TM strongly contributes to tumor progression, through long distance, cell-to-cell or cell-to-matrix signals, which influence different aspects of tumor cell behavior. Understanding the relationships among the different components of the cancer tissue is crucial to design and develop new therapeutic strategies. Ion channels are emerging as relevant players in the cross talk between tumor cells and their TM. Ion channels are expressed on tumor cells, as well as in the different cellular components of the TM. In all these cells, ion channels are in a strategic position to sense and transmit extracellular signals into the intracellular machinery. Often, this transmission is mediated by integrin adhesion receptors, which can be functional partners of ion channels since they form molecular complexes with the channel protein in the context of the plasma membrane. The same relevant role is exerted by ion transporters, which also contribute to determine two facets of the cancer tissue: hypoxia and the acidic extracellular pH. On the whole, it is conceivable to prospect the targeting of ion channels for new therapeutic strategies aimed at better controlling the malignant progression of the cancer tissue.